Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAX3_HUMAN
Description:paired box 3 [Source:HGNC Symbol;Acc:8617]
Location:chr2 q36.1
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T3___MTtLAGAVPhosphoSitePlus
T2____MtTLAGAPhosphoSitePlus
Y121KKIEEyKRENPPAXPhosphoSitePlus
S205QSDEGsDIDSEPhosphoSitePlus

Dephosphorylation site
PAX3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000343052V463DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000386750V462DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000375922V463DBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000342092*404SCOSMICCentral Nervous System Neoplasms10560660

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000343052Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3215169874

Hyperphosphorylation site
PAX3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PAX3_HUMANMITF_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PAX3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0007517muscle organ developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0021915neural tube developmentIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0048663neuron fate commitmentIEAbiological_process
GO:0001755neural crest cell migrationIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0071837HMG box domain bindingIEAmolecular_function
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0009887organ morphogenesisTASbiological_process
GO:0007605sensory perception of soundTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043565sequence-specific DNA bindingIDAmolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0021527spinal cord association neuron differentiationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0060594mammary gland specificationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0048066developmental pigmentationIEAbiological_process


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