| UniProt/SwissProt ID: | PAK7_HUMAN |
| Description: | p21 protein (Cdc42/Rac)-activated kinase 7 [Source:HGNC Symbol;Acc:15916] |
| Location: | chr20 p12.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S104 | SLRKEsPPTPD | RegPhos | |
| T107 | KESPPtPDQGA | RegPhos | |
| S573 | DIKSDsILLTS | PAK7 | HPRD |
| S345 | LSPPLsGSDTY | PhosphoSitePlus | |
| T606 | KSLVGtPYWMA | Pkinase | PhosphoSitePlus |
| S573 | DIKSDsILLTS | PAK5 | phosphoELM; RegPhos |
| S270 | DRRPKsSYLNQ | PhosphoSitePlus | |
| Y272 | RPKSSyLNQTS | PhosphoSitePlus | |
| Y350 | SGSDTyPRGPA | PhosphoSitePlus | |
| T349 | LSGSDtYPRGP | PhosphoSitePlus | |
| S602 | VPKRKsLVGTP | Pkinase | PhosphoSitePlus |
| S347 | PPLSGsDTYPR | PhosphoSitePlus | |
| Y182 | HGEAYySEVKP | PhosphoSitePlus | |
| S271 | RRPKSsYLNQT | PhosphoSitePlus | |
| S573 | DIKSDsILLTS | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| PAK7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000367686 | G704S | Greenman2007 | Skin Cancer | 17344846, 18428421 | ENSP00000322957 | S312P | Greenman2007 | Intestines Cancer | 17344846, 18428421 | ENSP00000322957 | P76T | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000322957 | G704S | Greenman2007 | Skin Cancer | 17344846, 18428421 | ENSP00000367679 | V604I | Greenman2007 | Skin Cancer | 17344846, 18428421 | ENSP00000367686 | S312P | HPI | Colorectal Cancer | 17344846 | ENSP00000367686 | T538N | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000367679 | S312C | Ding2008 | Lung Cancer | 18948947 | ENSP00000322957 | S312C | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000367679 | S312P | HPI | Colorectal Cancer | 17344846 | ENSP00000322957 | T538N | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000322957 | S312P | HPI | Colorectal Cancer | 17344846 | ENSP00000367679 | G704S | Greenman2007 | Skin Cancer | 17344846, 18428421 | ENSP00000367679 | T538N | Greenman2007, HPI | Lung Cancer | 16140923, 17344846, 18428421 | ENSP00000322957 | T397K | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000367686 | P76T | Ding2008 | Lung Cancer | 18948947 | ENSP00000367686 | T397K | Ding2008 | Lung Cancer | 18948947 | ENSP00000322957 | V604I | Greenman2007 | Skin Cancer | 17344846, 18428421 | ENSP00000367686 | S312P | Greenman2007 | Intestines Cancer | 17344846, 18428421 | ENSP00000367679 | S312P | Greenman2007 | Intestines Cancer | 17344846, 18428421 | ENSP00000367686 | S312C | Ding2008 | Lung Cancer | 18948947 | ENSP00000367686 | V604I | Greenman2007 | Skin Cancer | 17344846, 18428421 | ENSP00000367679 | P76T | Ding2008 | Lung Cancer | 18948947 | ENSP00000367679 | T397K | Ding2008 | Lung Cancer | 18948947 |
| Differential expressed protein |
| PAK7_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PAK7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | PAK7_HUMAN | kinase -> substrate | RegPhos |
| PAK7_HUMAN | PAK7_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PAK7_HUMAN | BAD_HUMAN | kinase -> substrate | HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| hsa04012 | ErbB signaling pathway |
| hsa04510 | Focal adhesion |
| hsa04660 | T cell receptor signaling pathway |
| hsa05211 | Renal cell carcinoma |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016049 | cell growth | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0007010 | cytoskeleton organization | TAS | biological_process |
| GO:0016477 | cell migration | TAS | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |