| UniProt/SwissProt ID: | P3C2A_HUMAN |
| Description: | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [Source:HGNC Symbol;Acc:8971] |
| Location: | chr11 p15.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y737 | YKNFFyLIKWD | PI3K_C2 | PhosphoSitePlus |
| S126 | PILSPsFSAQL | PhosphoSitePlus | |
| S259 | SNLQVsPKSED | CDC2(CDK1 | RegPhos; SysPTM |
| T120 | PVLPVtPILSP | PhosphoSitePlus | |
| Y73 | YNKQDyDLMVF | PhosphoSitePlus; HPRD | |
| S327 | KVNGKsLSVAT | PhosphoSitePlus | |
| Y1632 | LVYSGySKETL | C2 | PhosphoSitePlus |
| S1551 | SADAGsFSPTP | HPRD | |
| S672 | TDCAQsSKSVK | PhosphoSitePlus | |
| S6 | MAQISsNSGFK | PhosphoSitePlus | |
| S124 | VTPILsPSFSA | PhosphoSitePlus | |
| S771 | GILNQsSGSSP | PI3K_C2 | PhosphoSitePlus |
| S665 | ANSGRsPTDCA | PhosphoSitePlus | |
| S1553 | DAGSFsPTPGQ | PhosphoSitePlus; HPRD; SysPTM | |
| S1633 | VYSGYsKETLR | C2 | PhosphoSitePlus |
| S673 | DCAQSsKSVKE | PhosphoSitePlus | |
| S5 | _MAQIsSNSGF | PhosphoSitePlus | |
| Y900 | LWEKRyYCFKH | PI3Ka | PhosphoSitePlus |
| Y68 | KKAQVyNKQDY | PhosphoSitePlus | |
| Y1595 | ADPNPyVKTYL | C2 | PhosphoSitePlus |
| Y901 | WEKRYyCFKHP | PI3Ka | PhosphoSitePlus |
| S259 | SNLQVsPKSED | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S108 | LLLDDsFETKK | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S409 | PGYLLsPVTAQ | PI3K_rbd | PhosphoSitePlus |
| S234 | KIASTsEFLKN | PhosphoSitePlus | |
| S772 | ILNQSsGSSPD | PI3K_C2 | PhosphoSitePlus |
| S60 | FELSSsTRKKA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S338 | VTRSQsLNIRT | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S778 | GSSPDsNKQRK | PI3K_C2 | PhosphoSitePlus |
| S336 | ATVTRsQSLNI | PhosphoSitePlus | |
| S8 | QISSNsGFKEC | PhosphoSitePlus | |
| T667 | SGRSPtDCAQS | PhosphoSitePlus | |
| S259 | SNLQVsPKSED | CDK1 | phosphoELM; SysPTM |
| Dephosphorylation site |
| P3C2A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265970 | I1307M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265970 | N569I | COSMIC | Gastric Cancer | 21097718 | ENSP00000265970 | A916T | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000265970 | A650V | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000265970 | E1080D | COSMIC | Lung Cancer | 20668451 | ENSP00000265970 | F1206L | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000265970 | V600I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265970 | N359S | COSMIC | Lung Cancer | 20668451 | ENSP00000265970 | H400Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000265970 | R1081* | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000265970 | M1183V | Ding2008, COSMIC | Lung Cancer | 18948947 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000265970 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| P3C2A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK1_HUMAN | P3C2A_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | P3C2A_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa01100 | Metabolic pathways |
| hsa04070 | Phosphatidylinositol signaling system |
| hsa00562 | Inositol phosphate metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0048008 | platelet-derived growth factor receptor signaling | TAS | biological_process |
| GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic proc | IEA | biological_process |
| GO:0048015 | phosphatidylinositol-mediated signaling | IEA | biological_process |
| GO:0006644 | phospholipid metabolic process | TAS | biological_process |
| GO:0035004 | phosphatidylinositol 3-kinase activity | TAS | molecular_function |
| GO:0030136 | clathrin-coated vesicle | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0035091 | phosphatidylinositol binding | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0006897 | endocytosis | IMP | biological_process |
| GO:0006661 | phosphatidylinositol biosynthetic process | TAS | biological_process |
| GO:0048268 | clathrin coat assembly | TAS | biological_process |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0031982 | vesicle | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activi | TAS | molecular_function |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0014829 | vascular smooth muscle contraction | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007154 | cell communication | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016303 | 1-phosphatidylinositol-3-kinase activity | IEA | molecular_function |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0006887 | exocytosis | TAS | biological_process |