| UniProt/SwissProt ID: | P2RY2_HUMAN |
| Description: | purinergic receptor P2Y, G-protein coupled, 2 [Source:HGNC Symbol;Acc:8541] |
| Location: | chr11 q13.4 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S243 | RAKRKsVRTIA | 7tm_1; Sigma_reg_N | PhosphoSitePlus |
| S356 | DVLGSsEDSRR | PhosphoSitePlus | |
| S369 | STPAGsENTKD | PhosphoSitePlus | |
| T344 | RRSDRtDMQRI | PhosphoSitePlus | |
| T324 | DAKPPtGPSPA | PhosphoSitePlus | |
| T330 | GPSPAtPARRR | PhosphoSitePlus | |
| S327 | PPTGPsPATPA | PhosphoSitePlus | |
| Y71 | NASTTyMFHLA | TM; 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| P2RY2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377222 | A83V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000377222 | I127F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000310305 | I127F | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000377221 | R361P | COSMIC | Lung Cancer | 20668451 | ENSP00000377221 | A83V | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000377221 | I127F | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000310305 | A83V | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000377221 | R137Q | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| P2RY2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| P2RY2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P2RY2_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| P2RY2_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006873 | cellular ion homeostasis | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0070257 | positive regulation of mucus secretion | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007200 | phospholipase C-activating G-protein coupled recep | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0045028 | G-protein coupled purinergic nucleotide receptor a | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |