| UniProt/SwissProt ID: | OX2R_HUMAN |
| Description: | hypocretin (orexin) receptor 2 [Source:HGNC Symbol;Acc:4849] |
| Location: | chr6 p12.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y223 | IYPKMyHICFF | 7tm_1 | PhosphoSitePlus |
| T231 | CFFLVtYMAPL | 7tm_1; TM | PhosphoSitePlus |
| Y243 | LMVLAyLQIFR | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| OX2R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000359899 | A149T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000359899 | S194N | COSMIC | Breast Cancer | 20668451 | ENSP00000359899 | R168W | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000359899 | W251L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000359899 | P11fs*11 | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000359899 | L96V | COSMIC | Lung Cancer | 20668451 | ENSP00000359899 | Q423E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000359899 | R168W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000359899 | V424I | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| OX2R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| OX2R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| OREX_HUMAN | OX2R_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0007218 | neuropeptide signaling pathway | IEA | biological_process |
| GO:0017046 | peptide hormone binding | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0008188 | neuropeptide receptor activity | TAS | molecular_function |
| GO:0016499 | orexin receptor activity | IEA | molecular_function |
| GO:0007218 | neuropeptide signaling pathway | TAS | biological_process |
| GO:0007200 | phospholipase C-activating G-protein coupled recep | IEA | biological_process |
| GO:0007631 | feeding behavior | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |