Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:OX2R_HUMAN
Description:hypocretin (orexin) receptor 2 [Source:HGNC Symbol;Acc:4849]
Location:chr6 p12.1
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y223IYPKMyHICFF7tm_1PhosphoSitePlus
T231CFFLVtYMAPL7tm_1; TMPhosphoSitePlus
Y243LMVLAyLQIFR7tm_1; TMPhosphoSitePlus

Dephosphorylation site
OX2R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359899A149TBIOMARTBreast Cancer21930507, 21930502
ENSP00000359899S194NCOSMICBreast Cancer20668451
ENSP00000359899R168WTCGAOvarian Cancer21720365, 18772890
ENSP00000359899W251LCOSMICHead and Neck Cancer21798893
ENSP00000359899P11fs*11COSMICHead and Neck Cancer21798893
ENSP00000359899L96VCOSMICLung Cancer20668451
ENSP00000359899Q423EBIOMARTBreast Cancer21930507, 21930502
ENSP00000359899R168WCOSMICOvarian Cancer21720365
ENSP00000359899V424ICOSMICLung Cancer20668451

Differential expressed protein
OX2R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
OX2R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
OREX_HUMANOX2R_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneIEAcellular_component
GO:0007268synaptic transmissionTASbiological_process
GO:0007218neuropeptide signaling pathwayIEAbiological_process
GO:0017046peptide hormone bindingIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0008188neuropeptide receptor activityTASmolecular_function
GO:0016499orexin receptor activityIEAmolecular_function
GO:0007218neuropeptide signaling pathwayTASbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0007631feeding behaviorIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005886plasma membraneTAScellular_component


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