| UniProt/SwissProt ID: | ORC4_HUMAN |
| Description: | origin recognition complex, subunit 4 [Source:HGNC Symbol;Acc:8490] |
| Location: | chr2 q23.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S8 | SRKSKsNSLIH | PhosphoSitePlus; HPRD | |
| S235 | FKEQLsLPAEF | PhosphoSitePlus | |
| S48 | QYKHLsELLKR | PhosphoSitePlus | |
| S35 | RQSPHsNLFGV | HPRD | |
| Dephosphorylation site |
| ORC4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000441953 | I66F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000376597 | I66F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000376598 | I66F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000264169 | I66F | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| ORC4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ORC4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK4_HUMAN | ORC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK7_HUMAN | ORC4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ORC4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0017111 | nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0000808 | origin recognition complex | IEA | cellular_component |
| GO:0000084 | S phase of mitotic cell cycle | TAS | biological_process |
| GO:0000808 | origin recognition complex | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0000166 | nucleotide binding | IDA | molecular_function |
| GO:0005664 | nuclear origin of replication recognition complex | IDA | cellular_component |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006270 | DNA replication initiation | IMP | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000216 | M/G1 transition of mitotic cell cycle | TAS | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0003688 | DNA replication origin binding | IMP | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |