Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ORC4_HUMAN
Description:origin recognition complex, subunit 4 [Source:HGNC Symbol;Acc:8490]
Location:chr2 q23.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S8SRKSKsNSLIHPhosphoSitePlus; HPRD
S235FKEQLsLPAEFPhosphoSitePlus
S48QYKHLsELLKRPhosphoSitePlus
S35RQSPHsNLFGVHPRD

Dephosphorylation site
ORC4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000441953I66FCOSMICOvarian Cancer21720365
ENSP00000376597I66FCOSMICOvarian Cancer21720365
ENSP00000376598I66FCOSMICOvarian Cancer21720365
ENSP00000264169I66FCOSMICOvarian Cancer21720365

Differential expressed protein
ORC4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ORC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK4_HUMANORC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANORC4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ORC4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0000808origin recognition complexIEAcellular_component
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0000808origin recognition complexIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006260DNA replicationTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0000166nucleotide bindingIDAmolecular_function
GO:0005664nuclear origin of replication recognition complexIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006270DNA replication initiationIMPbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0003688DNA replication origin bindingIMPmolecular_function
GO:0005634nucleusIDAcellular_component


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