Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:OPTN_HUMAN
Description:optineurin [Source:HGNC Symbol;Acc:17142]
Location:chr10 p13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S177GSSEDsFVEIRPhosphoSitePlus; HPRD
S528ARTSDsDQQAYPhosphoSitePlus; HPRD; phosphoELM
S198KEIKHsPGPTRPhosphoSitePlus
Y356KQELVyTNKKLPhosphoSitePlus
S519LMEMQsRHGARPhosphoSitePlus
S173LNSSGsSEDSFHPRD
T209TVSTGtALSKYPhosphoSitePlus
S342LERKNsAIPSEPhosphoSitePlus; HPRD
T204PGPTRtVSTGTPhosphoSitePlus
S15TEKEDsPSESTPhosphoSitePlus
S17KEDSPsESTGNPhosphoSitePlus
T525RHGARtSDSDQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S473MEVYCsDFHAEPhosphoSitePlus
S170QLKLNsSGSSEHPRD
S526HGARTsDSDQQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S174NSSGSsEDSFVPhosphoSitePlus; HPRD
S171LKLNSsGSSEDPhosphoSitePlus; HPRD
T36NLDTFtPEELLPhosphoSitePlus
S513DGGRQsLMEMQPhosphoSitePlus
Y533SDQQAyLVQRGPhosphoSitePlus
S206PTRTVsTGTALPhosphoSitePlus

Dephosphorylation site
OPTN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263036Q398PCOSMICOvarian Cancer21720365
ENSP00000263036R548QCOSMICSkin Cancer21984974
ENSP00000368021E324QTCGAOvarian Cancer21720365, 18772890
ENSP00000263036E324QTCGAOvarian Cancer21720365, 18772890
ENSP00000263036E324QCOSMICOvarian Cancer21720365
ENSP00000263036Q398PTCGAOvarian Cancer21720365, 18772890
ENSP00000368032E324QTCGAOvarian Cancer21720365, 18772890
ENSP00000368022E324QTCGAOvarian Cancer21720365, 18772890
ENSP00000368032Q398PTCGAOvarian Cancer21720365, 18772890
ENSP00000368022Q398PTCGAOvarian Cancer21720365, 18772890
ENSP00000368021Q398PTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
OPTN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
OPTN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HIPK4_HUMANOPTN_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
OPTN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005794Golgi apparatusIDAcellular_component
GO:0000042protein targeting to GolgiIMPbiological_process
GO:0008219cell deathIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0043001Golgi to plasma membrane protein transportIMPbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0034613cellular protein localizationIEAbiological_process
GO:0090161Golgi ribbon formationIDAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0005802trans-Golgi networkIDAcellular_component
GO:0007030Golgi organizationIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function


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