| UniProt/SwissProt ID: | OPTN_HUMAN |
| Description: | optineurin [Source:HGNC Symbol;Acc:17142] |
| Location: | chr10 p13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S177 | GSSEDsFVEIR | PhosphoSitePlus; HPRD | |
| S528 | ARTSDsDQQAY | PhosphoSitePlus; HPRD; phosphoELM | |
| S198 | KEIKHsPGPTR | PhosphoSitePlus | |
| Y356 | KQELVyTNKKL | PhosphoSitePlus | |
| S519 | LMEMQsRHGAR | PhosphoSitePlus | |
| S173 | LNSSGsSEDSF | HPRD | |
| T209 | TVSTGtALSKY | PhosphoSitePlus | |
| S342 | LERKNsAIPSE | PhosphoSitePlus; HPRD | |
| T204 | PGPTRtVSTGT | PhosphoSitePlus | |
| S15 | TEKEDsPSEST | PhosphoSitePlus | |
| S17 | KEDSPsESTGN | PhosphoSitePlus | |
| T525 | RHGARtSDSDQ | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S473 | MEVYCsDFHAE | PhosphoSitePlus | |
| S170 | QLKLNsSGSSE | HPRD | |
| S526 | HGARTsDSDQQ | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S174 | NSSGSsEDSFV | PhosphoSitePlus; HPRD | |
| S171 | LKLNSsGSSED | PhosphoSitePlus; HPRD | |
| T36 | NLDTFtPEELL | PhosphoSitePlus | |
| S513 | DGGRQsLMEMQ | PhosphoSitePlus | |
| Y533 | SDQQAyLVQRG | PhosphoSitePlus | |
| S206 | PTRTVsTGTAL | PhosphoSitePlus | |
| Dephosphorylation site |
| OPTN_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263036 | Q398P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263036 | R548Q | COSMIC | Skin Cancer | 21984974 | ENSP00000368021 | E324Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000263036 | E324Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000263036 | E324Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000263036 | Q398P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000368032 | E324Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000368022 | E324Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000368032 | Q398P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000368022 | Q398P | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000368021 | Q398P | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| OPTN_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| OPTN_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| HIPK4_HUMAN | OPTN_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| OPTN_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0000042 | protein targeting to Golgi | IMP | biological_process |
| GO:0008219 | cell death | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0043001 | Golgi to plasma membrane protein transport | IMP | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0034613 | cellular protein localization | IEA | biological_process |
| GO:0090161 | Golgi ribbon formation | IDA | biological_process |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0005802 | trans-Golgi network | IDA | cellular_component |
| GO:0007030 | Golgi organization | IMP | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |