Phosphorylation

Protein information

UniProt/SwissProt ID:	OAS1_HUMAN
Description:	2'-5'-oligoadenylate synthetase 1, 40/46kDa [Source:HGNC Symbol;Acc:8086]
Location:	chr12 q24.13
Node attribute:	substrate

Position	PhosphoPeptide	Catalytic kinase	Source
Y271	QQLCIyWTKYY	OAS1_C	PhosphoSitePlus
Y362	DDPRRyQKYGY		PhosphoSitePlus

OAS1_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000388001	E175K	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000388001	V262L	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000415721	S352F	BIOMART	Breast Cancer	21930507, 21930502

OAS1_HUMAN is not differential expressed protein.

OAS1_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
FGFR2_HUMAN	OAS1_HUMAN	kinase -> substrate	Robert H Newman (2013)

KEGG Pathway

OAS1_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0008270	zinc ion binding	IDA	molecular_function
GO:0016779	nucleotidyltransferase activity	IEA	molecular_function
GO:0035457	cellular response to interferon-alpha	IDA	biological_process
GO:0005737	cytoplasm	IDA	cellular_component
GO:0001730	2'-5'-oligoadenylate synthetase activity	IDA	molecular_function
GO:0005739	mitochondrion	IEA	cellular_component
GO:0060700	regulation of ribonuclease activity	IDA	biological_process
GO:0005783	endoplasmic reticulum	IEA	cellular_component
GO:0046872	metal ion binding	IEA	molecular_function
GO:0003723	RNA binding	IEA	molecular_function
GO:0009615	response to virus	IDA	biological_process
GO:0060337	type I interferon-mediated signaling pathway	TAS	biological_process
GO:0005634	nucleus	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0051259	protein oligomerization	IDA	biological_process
GO:0006164	purine nucleotide biosynthetic process	IDA	biological_process
GO:0019221	cytokine-mediated signaling pathway	TAS	biological_process
GO:0016740	transferase activity	IEA	molecular_function
GO:0006955	immune response	IEA	biological_process
GO:0005524	ATP binding	TAS	molecular_function
GO:0045071	negative regulation of viral genome replication	IDA	biological_process
GO:0060333	interferon-gamma-mediated signaling pathway	TAS	biological_process
GO:0003725	double-stranded RNA binding	IDA	molecular_function
GO:0051607	defense response to virus	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network