Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NUP53_HUMAN
Description:nucleoporin 35kDa [Source:HGNC Symbol;Acc:29797]
Location:chr2 q32.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T280TQPGStPRISTPhosphoSitePlus; HPRD; phosphoELM
S58SISGPsVGVMEPhosphoSitePlus; HPRD; phosphoELM
S99IYDDIsSPGLGPhosphoSitePlus; HPRD; phosphoELM
S128LVGVTsTPGTGHPRD; phosphoELM
S121ISVMQsPLVGVPhosphoSitePlus; HPRD; phosphoELM
S279PTQPGsTPRISPhosphoSitePlus; HPRD; phosphoELM
S261ALSSPsLAFTPPhosphoSitePlus
T265PSLAFtPPIKTPhosphoSitePlus; HPRD; phosphoELM
S100YDDISsPGLGSPhosphoSitePlus; HPRD; phosphoELM
S258DRCALsSPSLAPhosphoSitePlus
S314PKKDEsLVSKAPhosphoSitePlus; HPRD
S252SVMESsDRCALNup35_RRMPhosphoSitePlus
S25LGSPTsPKPGVHPRD
T285TPRIStMRPLAPhosphoSitePlus
T106PGLGStPLTSRPhosphoSitePlus; HPRD; phosphoELM
S53TPQPRsISGPSPhosphoSitePlus
Y300ASTSDyQVISDPhosphoSitePlus
T109GSTPLtSRRQPHPRD
T129VGVTStPGTGQPhosphoSitePlus; HPRD; phosphoELM
T273IKTLGtPTQPGPhosphoSitePlus; HPRD; phosphoELM
T24MLGSPtSPKPGHPRD
S304DYQVIsDRQTPPhosphoSitePlus
S93APPVRsIYDDIPhosphoSitePlus; HPRD
S15GPALGsEPMMLHPRD
S138GQSMFsPASIGPhosphoSitePlus; HPRD; phosphoELM
S105SPGLGsTPLTSPhosphoSitePlus; HPRD
Y95PVRSIyDDISSPhosphoSitePlus
T270TPPIKtLGTPTPhosphoSitePlus
T308ISDRQtPKKDEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S55QPRSIsGPSVGPhosphoSitePlus; HPRD; phosphoELM
T48LPAPVtPQPRSPhosphoSitePlus; HPRD
T275TLGTPtQPGSTPhosphoSitePlus; HPRD; phosphoELM
S22PMMLGsPTSPKHPRD
T132TSTPGtGQSMFHPRD; phosphoELM
S73LLAGGsPPQPVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S284STPRIsTMRPLPhosphoSitePlus
S66VMEMRsPLLAGPhosphoSitePlus; HPRD; phosphoELM
S259RCALSsPSLAFPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
NUP53_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295119P89TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000295119Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.318646787

Hyperphosphorylation site
NUP53_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BUB1_HUMANNUP53_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANNUP53_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANNUP53_HUMANkinase -> substrateRobert H Newman (2013)
NEK3_HUMANNUP53_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NUP53_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0015758glucose transportTASbiological_process
GO:0008645hexose transportTASbiological_process
GO:0055085transmembrane transportIEAbiological_process
GO:0051028mRNA transportIEAbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0015031protein transportIEAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0010827regulation of glucose transportTASbiological_process
GO:0005635nuclear envelopeTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0045111intermediate filament cytoskeletonIDAcellular_component
GO:0005643nuclear poreIEAcellular_component
GO:0019221cytokine-mediated signaling pathwayTASbiological_process