| UniProt/SwissProt ID: | NUAK2_HUMAN |
| Description: | NUAK family, SNF1-like kinase, 2 [Source:HGNC Symbol;Acc:29558] |
| Location: | chr1 q32.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S553 | ILSSEsFDQLD | PhosphoSitePlus | |
| T208 | GKFLQtFCGSP | LKB1 | phosphoELM |
| S585 | LEEPPsEGPGS | RegPhos | |
| T208 | GKFLQtFCGSP | LKB1(STK11 | RegPhos |
| Y267 | ISNGAyREPPK | Pkinase_CAMK | PhosphoSitePlus |
| S435 | SPIPAsPGQAA | PhosphoSitePlus | |
| S386 | NDMAQsLHSDT | RegPhos | |
| S212 | QTFCGsPLYAS | RegPhos | |
| T208 | GKFLQtFCGSP | RegPhos | |
| S547 | AVSEDsILSSE | PhosphoSitePlus | |
| S462 | SGYYSsPEPSE | PhosphoSitePlus | |
| S523 | PTTFGsLDELA | PhosphoSitePlus | |
| T208 | GKFLQtFCGSP | Pkinase_CAMK | PhosphoSitePlus |
| S377 | HSLKKsRKEND | RegPhos | |
| Y140 | GDLYDyISERQ | Pkinase_CAMK | PhosphoSitePlus |
| Y131 | VIVMEyASRGD | Pkinase_CAMK | PhosphoSitePlus |
| S544 | PSGAVsEDSIL | PhosphoSitePlus | |
| S142 | LYDYIsERQQL | Pkinase_CAMK | PhosphoSitePlus |
| Y138 | SRGDLyDYISE | Pkinase_CAMK | PhosphoSitePlus |
| Dephosphorylation site |
| NUAK2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356125 | K503R | Greenman2007, HPI | Ovarian Cancer | 17344846, 18428421 | ENSP00000356125 | G541E | Greenman2007, HPI | Breast Cancer | 15908952, 17344846, 18428421 |
| Differential expressed protein |
| NUAK2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NUAK2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | NUAK2_HUMAN | kinase -> substrate | RegPhos |
| STK11_HUMAN | NUAK2_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NUAK2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0042149 | cellular response to glucose starvation | IDA | biological_process |
| GO:0030036 | actin cytoskeleton organization | IDA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IDA | biological_process |
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |