Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NTRK2_HUMAN
Description:neurotrophic tyrosine kinase, receptor, type 2 [Source:HGNC Symbol;Acc:8032]
Location:chr9 q21.33
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y702MSRDVySTDYYTRKBRegPhos
Y706VYSTDyYRVGGPkinase_TyrPhosphoSitePlus
S260ISSDDsGKQISI-setPhosphoSitePlus
T506VIIGMtKIPVIPhosphoSitePlus
Y702MSRDVySTDYYautocatalysis RegPhos
Y516IENPQyFGITNautocatalysis RegPhos
Y702MSRDVySTDYYNTRK2HPRD
Y817KASPVyLDILGTRKBRegPhos
Y722VYSTDyYRVGGNTRK2HPRD
Y702MSRDVySTDYYPkinase_TyrPhosphoSitePlus
T151VGNPFtCSCDIPhosphoSitePlus
Y707YSTDYyRVGGHPkinase_TyrPhosphoSitePlus
Y706VYSTDyYRVGGautocatalysis RegPhos
Y833KASPVyLDINTRK2HPRD
T161IMWIKtLQEAKPhosphoSitePlus
Y817KASPVyLDINTRK2HPRD
S153NPFTCsCDIMWPhosphoSitePlus
S141RHLDLsELILVLRR_8PhosphoSitePlus
Y516IENPQyFGITNPhosphoSitePlus
Y532IENPQyFGITNNTRK2HPRD
Y723YSTDYyRVGGHNTRK2HPRD
Y817KASPVyLDILGautocatalysis RegPhos
Y707YSTDYyRVGGHautocatalysis RegPhos
Y707YSTDYyRVGGHNTRK2HPRD
Y706VYSTDyYRVGGNTRK2HPRD
Y516IENPQyFGITNNTRK2HPRD
S698GDFGMsRDVYSPkinase_TyrPhosphoSitePlus
Y707YSTDYyRVGGHTRKBRegPhos
T573LVAVKtLKDASPkinase_TyrPhosphoSitePlus
Y706VYSTDyYRVGGTRKBRegPhos
Y516IENPQyFGITNTRKBRegPhos
Y718MSRDVySTDYYNTRK2HPRD

Dephosphorylation site
NTRK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365387A199TBIOMARTchronic lymphocytic leukemia21930507, 21930502
ENSP00000365387L138FGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000365386M697IHPILung Cancer18293376
ENSP00000379221A11VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000365386R718CHPILung Cancer18293376
ENSP00000365386L138FGreenman2007, HPILung Cancer16140923, 17344846, 18428421, 17344846, 21379385, 17344846 21379385
ENSP00000277120Q666RDing2008Lung Cancer18948947
ENSP00000379221W158*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000365387Q666RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000277120A656DDing2008Lung Cancer18948947
ENSP00000365387G261RBIOMARTLung Cancer21930507, 21930502
ENSP00000277120L670MDing2008Lung Cancer18948947
ENSP00000277120T793ABIOMARTBrain Cancer21930507, 21930502
ENSP00000277120E559DDing2008Lung Cancer18948947
ENSP00000314586R699GHPILung Cancer18293376
ENSP00000365387L670MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000365387E559DDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000314586L138FGreenman2007, HPILung Cancer16140923, 17344846, 18428421, 17344846, 21379385, 17344846 21379385
ENSP00000277120L138FGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000379221A286TBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000352906A11VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000365387W158*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000365387G261RDing2008Lung Cancer18948947
ENSP00000352906W158*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000365386W158*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000365387A656DDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000277120C45FDing2008Lung Cancer18948947
ENSP00000314586R718CHPILung Cancer18293376
ENSP00000277120W158*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000314586M697IHPILung Cancer18293376
ENSP00000365381W158*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000277120G261RDing2008Lung Cancer18948947
ENSP00000365387C45FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000306167W158*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000314586W158*BIOMARTPancreatic Cancer21930507, 21930502
ENSP00000365386R699GHPILung Cancer18293376

Differential expressed protein
NTRK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NTRK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NTRK2_HUMANNTRK2_HUMANkinase -> substrateRegPhos
NTRK2_HUMANFRS3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa05034Alcoholism
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIEAbiological_process
GO:0007612learningIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0035584calcium-mediated signaling using intracellular calIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0005887integral to plasma membraneIEAcellular_component
GO:0008284positive regulation of cell proliferationISSbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0050772positive regulation of axonogenesisIEAbiological_process
GO:0010996response to auditory stimulusIEAbiological_process
GO:0031547brain-derived neurotrophic factor receptor signaliIEAbiological_process
GO:0043410positive regulation of MAPK cascadeISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0010008endosome membraneIEAcellular_component
GO:0014069postsynaptic densityIEAcellular_component
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0042490mechanoreceptor differentiationIEAbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0060175brain-derived neurotrophic factor-activated receptIMPmolecular_function
GO:0043408regulation of MAPK cascadeIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0032314regulation of Rac GTPase activityIEAbiological_process
GO:0046777protein autophosphorylationISSbiological_process
GO:0010628positive regulation of gene expressionISSbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:2000811negative regulation of anoikisIEAbiological_process
GO:0043679axon terminusIEAcellular_component
GO:0014068positive regulation of phosphatidylinositol 3-kinaISSbiological_process
GO:0001764neuron migrationISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0021954central nervous system neuron developmentISSbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0021954central nervous system neuron developmentIEAbiological_process
GO:0005030neurotrophin receptor activityIEAmolecular_function
GO:0007631feeding behaviorIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0019222regulation of metabolic processIEAbiological_process
GO:0014047glutamate secretionIEAbiological_process
GO:0046875ephrin receptor bindingIEAmolecular_function
GO:0048403brain-derived neurotrophic factor bindingISSmolecular_function
GO:0030424axonIEAcellular_component
GO:0007612learningISSbiological_process
GO:0030426growth coneIEAcellular_component
GO:0030425dendriteIEAcellular_component
GO:0030182neuron differentiationISSbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0060076excitatory synapseIEAcellular_component
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0060175brain-derived neurotrophic factor-activated receptIEAmolecular_function
GO:0043197dendritic spineIEAcellular_component
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0051896regulation of protein kinase B signaling cascadeIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0048786presynaptic active zoneIEAcellular_component
GO:0021987cerebral cortex developmentISSbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0007616long-term memoryIEAbiological_process
GO:0010976positive regulation of neuron projection developmeISSbiological_process
GO:0032314regulation of Rac GTPase activityISSbiological_process
GO:0005829cytosolIEAcellular_component
GO:0001764neuron migrationIEAbiological_process
GO:0007190activation of adenylate cyclase activityTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0050772positive regulation of axonogenesisISSbiological_process
GO:0043121neurotrophin bindingISSmolecular_function
GO:0048709oligodendrocyte differentiationIEAbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0031547brain-derived neurotrophic factor receptor signaliIMPbiological_process
GO:0046928regulation of neurotransmitter secretionIEAbiological_process
GO:0050773regulation of dendrite developmentIEAbiological_process
GO:0046548retinal rod cell developmentIEAbiological_process
GO:0048935peripheral nervous system neuron developmentIEAbiological_process
GO:0042803protein homodimerization activityISSmolecular_function
GO:0043524negative regulation of neuron apoptotic processISSbiological_process
GO:0051968positive regulation of synaptic transmission, glutIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0010976positive regulation of neuron projection developmeIEAbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0048403brain-derived neurotrophic factor bindingIEAmolecular_function
GO:0030182neuron differentiationIEAbiological_process