| UniProt/SwissProt ID: | NRP2_HUMAN |
| Description: | neuropilin 2 [Source:HGNC Symbol;Acc:8005] |
| Location: | chr2 q33.3 |
| Node attribute: | receptor |
| Phosphorylation site |
| NRP2_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| NRP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353582 | W754L | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000349632 | E351* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000272849 | E351* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000353582 | R310Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000353582 | T861I | COSMIC | Melanoma | 21499247 | ENSP00000272849 | A98T | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000353582 | E351* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350432 | E351* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000407626 | E351* | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000353582 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| NRP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SEM3C_HUMAN | NRP2_HUMAN | ligand -> receptor | HPMR |
| VEGFD_HUMAN | NRP2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| NRP2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | NAS | cellular_component |
| GO:0071526 | semaphorin-plexin signaling pathway | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0030424 | axon | IEA | cellular_component |
| GO:0017154 | semaphorin receptor activity | IEA | molecular_function |
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0005021 | vascular endothelial growth factor-activated recep | NAS | molecular_function |
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0002116 | semaphorin receptor complex | NAS | cellular_component |
| GO:0019838 | growth factor binding | TAS | molecular_function |
| GO:0050919 | negative chemotaxis | IEA | biological_process |
| GO:0038084 | vascular endothelial growth factor signaling pathw | NAS | biological_process |
| GO:0001525 | angiogenesis | NAS | biological_process |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0048010 | vascular endothelial growth factor receptor signal | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007411 | axon guidance | IEA | biological_process |
| GO:0019955 | cytokine binding | NAS | molecular_function |
| GO:0007507 | heart development | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0007155 | cell adhesion | NAS | biological_process |
| GO:0010595 | positive regulation of endothelial cell migration | TAS | biological_process |
| GO:0001938 | positive regulation of endothelial cell proliferat | TAS | biological_process |
| GO:0001755 | neural crest cell migration | IEA | biological_process |