| UniProt/SwissProt ID: | NRG3_HUMAN |
| Description: | neuregulin 3 [Source:HGNC Symbol;Acc:7999] |
| Location: | chr10 q23.1 |
| Node attribute: | ligand; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S119 | FLSKPsSFPKA | PhosphoSitePlus | |
| T278 | KFHTTtYSTER | PhosphoSitePlus | |
| Y405 | QNGKSySLKAS | PhosphoSitePlus | |
| T609 | VGLEEtCLQMP | PhosphoSitePlus | |
| Y357 | ESEEVyQRQVL | Neuregulin | PhosphoSitePlus |
| S116 | DPFFLsKPSSF | PhosphoSitePlus | |
| S255 | AASSSsSSSSS | PhosphoSitePlus | |
| S257 | SSSSSsSSSAT | PhosphoSitePlus | |
| S254 | DAASSsSSSSS | PhosphoSitePlus | |
| S256 | ASSSSsSSSSA | PhosphoSitePlus | |
| T156 | PNRIStRLTTI | PhosphoSitePlus | |
| S410 | YSLKAsSTMAK | PhosphoSitePlus | |
| Dephosphorylation site |
| NRG3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361214 | G591E | COSMIC | Skin Cancer | 21984974 | ENSP00000361214 | A164S | COSMIC | Lung Cancer | 20668451 | ENSP00000361214 | T276R | COSMIC | Lung Cancer | 20668451 | ENSP00000361214 | S238C | COSMIC | Breast Cancer | 20668451 | ENSP00000361214 | W600S | COSMIC | Lung Cancer | 20668451 | ENSP00000361214 | L407P | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000361214 | A661V | COSMIC | Lung Cancer | 20668451 | ENSP00000361214 | V98M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000361214 | D562H | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 | ENSP00000361214 | R185W | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| NRG3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NRG3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NRG3_HUMAN | ERBB4_HUMAN | ligand -> receptor | HPMR |
| NRG3_HUMAN | ERBB4_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04012 | ErbB signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:0005102 | receptor binding | IEA | molecular_function |
| GO:0001558 | regulation of cell growth | NAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007171 | activation of transmembrane receptor protein tyros | NAS | biological_process |
| GO:0008083 | growth factor activity | NAS | molecular_function |
| GO:0030297 | transmembrane receptor protein tyrosine kinase act | NAS | molecular_function |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0007243 | intracellular protein kinase cascade | IEA | biological_process |
| GO:0030971 | receptor tyrosine kinase binding | NAS | molecular_function |
| GO:0009790 | embryo development | IEA | biological_process |
| GO:0007389 | pattern specification process | IEA | biological_process |
| GO:0060596 | mammary placode formation | IEA | biological_process |
| GO:0030879 | mammary gland development | IEA | biological_process |