| UniProt/SwissProt ID: | NRF1_HUMAN |
| Description: | nuclear respiratory factor 1 [Source:HGNC Symbol;Acc:7996] |
| Location: | chr7 q32.2 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S136 | IVLCIsPSKPN | Nrf1_DNA-bind | PhosphoSitePlus |
| T118 | RKLRAtLDEYT | Nrf1_DNA-bind | PhosphoSitePlus |
| S99 | PHVFEsNPSIR | Nrf1_DNA-bind | PhosphoSitePlus |
| T123 | TLDEYtTRVGQ | Nrf1_DNA-bind | PhosphoSitePlus |
| T259 | QRVSWtQALRT | Nrf1_DNA-bind | PhosphoSitePlus |
| Y122 | ATLDEyTTRVG | Nrf1_DNA-bind | PhosphoSitePlus |
| Dephosphorylation site |
| NRF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000223190 | Q272L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000376922 | Q272L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000223190 | Q272L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000376924 | Q272L | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| NRF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NRF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NRF1_HUMAN | EIF2A_HUMAN | TF -> target gene | TRANSFAC |
| NRF1_HUMAN | E2F1_HUMAN | TF -> target gene | TRANSFAC |
| NRF1_HUMAN | TFAM_HUMAN | TF -> target gene | TRANSFAC |
| NRF1_HUMAN | QCR7_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| NRF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0031100 | organ regeneration | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0032355 | response to estradiol stimulus | IEA | biological_process |
| GO:0032496 | response to lipopolysaccharide | IEA | biological_process |
| GO:0051593 | response to folic acid | IEA | biological_process |
| GO:0051602 | response to electrical stimulus | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0001666 | response to hypoxia | IEA | biological_process |
| GO:0007005 | mitochondrion organization | IEA | biological_process |
| GO:0006091 | generation of precursor metabolites and energy | TAS | biological_process |