Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NR1I2_HUMAN
Description:nuclear receptor subfamily 1, group I, member 2 [Source:HGNC Symbol;Acc:7968]
Location:chr3 q13.33
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S305ECGRLsYCLEDHormone_recepPhosphoSitePlus
S256FKGIIsFAKVIHormone_recepPhosphoSitePlus
T290QLRFNtVFNAEHormone_recepPhosphoSitePlus
S350AISLFsPDRPGHormone_recepPhosphoSitePlus
S208RKDLCsLKVSLPhosphoSitePlus
T408INAQHtQRLLRHormone_recepPhosphoSitePlus
T57HFNVMtCEGCKzf-C4PhosphoSitePlus
S8VRPKEsWNHADPhosphoSitePlus
S274IEDQIsLLKGAHormone_recepPhosphoSitePlus

Dephosphorylation site
NR1I2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000336528S295NCOSMICOvarian Cancer20826764
ENSP00000336528P458SBIOMARTBreast Cancer21930507, 21930502
ENSP00000336528G256WCOSMICOvarian Cancer21720365
ENSP00000336528*474GCOSMICOvarian Cancer21720365
ENSP00000336528S61CCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000336528Gastric CancerTreatment (none vs. 5-fluorouracil treatment)cell lineDown0.1116900703

Hyperphosphorylation site
NR1I2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NR1I2_HUMANU627C_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
NR1I2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0030522intracellular receptor mediated signaling pathwayIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0006805xenobiotic metabolic processIDAbiological_process
GO:0008202steroid metabolic processTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0003713transcription coactivator activityTASmolecular_function
GO:0008144drug bindingIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIDAmolecular_function
GO:0042738exogenous drug catabolic processIDAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0042908xenobiotic transportIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0046618drug exportIDAbiological_process


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