| UniProt/SwissProt ID: | NPFF2_HUMAN |
| Description: | neuropeptide FF receptor 2 [Source:HGNC Symbol;Acc:4525] |
| Location: | chr4 q13.3 |
| Node attribute: | receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S280 | TIMSPsAVMLH | 7tm_1; TM | PhosphoSitePlus |
| Y465 | KPMEAyALKAK | PhosphoSitePlus | |
| Dephosphorylation site |
| NPFF2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000307822 | C455R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000307822 | A459S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000351599 | Y204C | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000307822 | W115C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000307822 | V353A | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000307822 | I149V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000340789 | *133K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| NPFF2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NPFF2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NPFF_HUMAN | NPFF2_HUMAN | ligand -> receptor | HPMR |
| IP3KA_HUMAN | NPFF2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0015629 | actin cytoskeleton | IDA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0008188 | neuropeptide receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0009582 | detection of abiotic stimulus | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |