| UniProt/SwissProt ID: | NPBW2_HUMAN |
| Description: | neuropeptides B/W receptor 2 [Source:HGNC Symbol;Acc:4530] |
| Location: | chr20 q13.33 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y143 | MSVDRyLVVLA | 7tm_1 | PhosphoSitePlus |
| Y126 | LAVDHyNIFSS | 7tm_1; TM | PhosphoSitePlus |
| Y133 | IFSSIyFLAVM | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| NPBW2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358783 | G92R | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000358783 | G92R | HPI | Colorectal Cancer | 16959974 | ENSP00000358783 | R161W | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| NPBW2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NPBW2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NPW_HUMAN | NPBW2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0038003 | opioid receptor signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0016021 | integral to membrane | IC | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004985 | opioid receptor activity | TAS | molecular_function |