| UniProt/SwissProt ID: | NONO_HUMAN |
| Description: | non-POU domain containing, octamer-binding [Source:HGNC Symbol;Acc:7871] |
| Location: | chrX q13.1 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T418 | PPGPAtMMPDG | PhosphoSitePlus | |
| Y267 | SFEYEyAMRWK | NOPS | PhosphoSitePlus |
| S188 | DRGRPsGKGIV | RRM_1 | PhosphoSitePlus |
| T410 | PVPAGtPAPPG | PhosphoSitePlus | |
| S209 | ALDRCsEGSFL | HPRD | |
| T431 | GLTPPtTERFG | PhosphoSitePlus | |
| T151 | HSASLtVRNLP | RRM_1 | PhosphoSitePlus |
| T432 | LTPPTtERFGQ | PhosphoSitePlus; HPRD; SysPTM | |
| S149 | ACHSAsLTVRN | RRM_1 | PhosphoSitePlus; SysPTM |
| Y265 | PGSFEyEYAMR | NOPS | PhosphoSitePlus |
| S149 | ACHSAsLTVRN | HPRD; SysPTM | |
| T424 | MMPDGtLGLTP | PhosphoSitePlus; HPRD | |
| T428 | GTLGLtPPTTE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S262 | FAQPGsFEYEY | NOPS | PhosphoSitePlus |
| T450 | GAIGGtPPAFN | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y471 | NKRRRy_____ | PhosphoSitePlus | |
| S147 | RFACHsASLTV | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S188 | DRGRPsGKGIV | HPRD | |
| T15 | EKQNHtPRKHH | PhosphoSitePlus; HPRD | |
| T440 | FGQAAtMEGIG | PhosphoSitePlus; HPRD; SysPTM | |
| Dephosphorylation site |
| NONO_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362963 | F213L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362947 | F213L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000276079 | F213L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000362963 | F213L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000276079 | F213L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362947 | F213L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000276079 | R256S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000362963 | R256S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000362947 | R256S | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000362947 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000362947 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Down | 0.65 | 20625496 |
| Hyperphosphorylation site |
| NONO_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NONO_HUMAN | MPCP_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| NONO_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0005730 | nucleolus | IEA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006397 | mRNA processing | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0042382 | paraspeckles | IDA | cellular_component |
| GO:0016363 | nuclear matrix | IDA | cellular_component |
| GO:0008380 | RNA splicing | IEA | biological_process |