Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NMUR2_HUMAN
Description:neuromedin U receptor 2 [Source:HGNC Symbol;Acc:16454]
Location:chr5 q33.1
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y407MSRTNyQSFHFPhosphoSitePlus

Dephosphorylation site
NMUR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000255262M269VCOSMICBreast Cancer20668451
ENSP00000255262T205MCOSMICOvarian Cancer21720365
ENSP00000255262S298ICOSMICLung Cancer20668451
ENSP00000255262C119FCOSMICOvarian Cancer20668451
ENSP00000255262E127GCOSMICPancreatic Cancer20668451
ENSP00000255262H309YCOSMICMelanoma21499247
ENSP00000255262Y407CCOSMICHead and Neck Cancer21798893
ENSP00000255262I232NCOSMICMelanoma21499247

Differential expressed protein
NMUR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NMUR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NMS_HUMANNMUR2_HUMANligand -> receptorHPMR
NMU_HUMANNMUR2_HUMANligand -> receptorHPMR
NMUR2_HUMANGNAQ_HUMANGPCR -> GproteingpDB
NMUR2_HUMANGNA11_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007218neuropeptide signaling pathwayTASbiological_process
GO:0048265response to painIEAbiological_process
GO:0043006activation of phospholipase A2 activity by calciumIDAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0016021integral to membraneIDAcellular_component
GO:0050482arachidonic acid secretionIDAbiological_process
GO:0005229intracellular calcium activated chloride channel aIDAmolecular_function
GO:0008188neuropeptide receptor activityIEAmolecular_function
GO:0007417central nervous system developmentIEPbiological_process
GO:0006816calcium ion transportIDAbiological_process
GO:0007631feeding behaviorTASbiological_process
GO:0048016inositol phosphate-mediated signalingIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006940regulation of smooth muscle contractionNASbiological_process
GO:0001607neuromedin U receptor activityIDAmolecular_function
GO:0002023reduction of food intake in response to dietary exIEAbiological_process
GO:0019722calcium-mediated signalingNASbiological_process
GO:0007625grooming behaviorIEAbiological_process
GO:0042924neuromedin U bindingIDAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIDAbiological_process
GO:0005525GTP bindingIDAmolecular_function
GO:0007218neuropeptide signaling pathwayIEAbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIDAbiological_process


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