| UniProt/SwissProt ID: | NMBR_HUMAN |
| Description: | neuromedin B receptor [Source:HGNC Symbol;Acc:7843] |
| Location: | chr6 q24.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y288 | HILYMyRSFNY | 7tm_1 | PhosphoSitePlus |
| S352 | QERGTsYLLSS | PhosphoSitePlus | |
| S130 | TSVGVsVFTLT | 7tm_1; TM | PhosphoSitePlus |
| Y286 | PNHILyMYRSF | 7tm_1; TM | PhosphoSitePlus |
| T351 | YQERGtSYLLS | PhosphoSitePlus | |
| S356 | TSYLLsSSAVR | PhosphoSitePlus | |
| Dephosphorylation site |
| NMBR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000258042 | G381R | COSMIC | Breast Cancer | 20668451 | ENSP00000258042 | Y346C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000258042 | S102L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000258042 | A86V | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000258042 | V56M | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000258042 | P148H | COSMIC | Central Nervous System Neoplasms | 18772890 |
| Differential expressed protein |
| NMBR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NMBR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NMB_HUMAN | NMBR_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004946 | bombesin receptor activity | IEA | molecular_function |
| GO:0007200 | phospholipase C-activating G-protein coupled recep | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |