Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFAC1_HUMAN
Description:nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [Source:HGNC Symbol;Acc:7775]
Location:chr18 q23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T504GKTVStTSHEARHDPhosphoSitePlus
T912APIPVtVKREPPhosphoSitePlus
Y197NYSYPyASPQTPhosphoSitePlus
S526LLPENsMRAVIRHDPhosphoSitePlus
S245TSPRAsVTEESPKCaRegPhos
S294GSPRVsVTDDSPKA_groupphosphoELM; RegPhos
S542LKLRNsDIELRRHDPhosphoSitePlus
S169AYRDPsCLSPAPhosphoSitePlus
S887VRRDEsPTAGPPhosphoSitePlus
Y371FAPEDySSFQHPhosphoSitePlus
S256NKRKYsLNGRQPRKCAHPRD
S281GSPRVsVTDDSPRKCAHPRD
S172DPSCLsPASSLPhosphoSitePlus
S269NKRKYsLNGRQPRKCAHPRD
S903VHEDGsPNLAPPhosphoSitePlus
S232TSPRAsVTEESPRKCAHPRD
Y426SHSGPyELRIEPhosphoSitePlus
S294GSPRVsVTDDSPRKCAHPRD
S256WLGARsSRPASPKCaRegPhos
S269NKRKYsLNGRQPKCaRegPhos
Y709EPTDDyEPAPTPhosphoSitePlus
S233CTLLGsPRHSPPhosphoSitePlus; HPRD
S294GSPRVsVTDDSPKCaRegPhos
S245TSPRAsVTEESPhosphoSitePlus
S294GSPRVsVTDDSPhosphoSitePlus
Y386GFCDQyLAVPQPhosphoSitePlus
S269NKRKYsLNGRQPKA_groupphosphoELM; RegPhos
S117APALEsPRIEIRegPhos
Y394VPQHPyQWAKPPhosphoSitePlus
S184SRSCNsEASSYPhosphoSitePlus
S245TSPRAsVTEESPKA_groupphosphoELM; RegPhos
S269NKRKYsLNGRQPhosphoSitePlus
S187CNSEAsSYESNPhosphoSitePlus
S512HEAILsNTKVLRHDPhosphoSitePlus
S250SVTEEsWLGARPhosphoSitePlus
S220CTLLGsPRHSPHPRD
S261SSRPAsPCNKRPhosphoSitePlus
S670NQRITsPVHVSTIGPhosphoSitePlus
S245TSPRAsVTEESPRKCAHPRD

Dephosphorylation site
NFAC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000253506A315TBIOMARTColorectal Cancer21930507, 21930502
ENSP00000327850P397LCOSMICOvarian Cancer21720365
ENSP00000316553A315THPIColorectal Cancer16959974
ENSP00000253506A315TSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000327850T201ICOSMICSkin Cancer21984974
ENSP00000327850A302TCOSMICIntestines Cancer16959974

Differential expressed protein
NFAC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NFAC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNFAC1_HUMANkinase -> substrateRegPhos
KPCA_HUMANNFAC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04360Axon guidance
hsa04380Osteoclast differentiation
hsa04310Wnt signaling pathway
hsa05166HTLV-I infection
hsa04370VEGF signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0000790nuclear chromatinIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0048273mitogen-activated protein kinase p38 bindingISSmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005667transcription factor complexIEAcellular_component
GO:0001205RNA polymerase II distal enhancer sequence-specifiISSmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005528FK506 bindingTASmolecular_function
GO:0000980RNA polymerase II distal enhancer sequence-specifiISSmolecular_function
GO:0001837epithelial to mesenchymal transitionIEAbiological_process
GO:0001085RNA polymerase II transcription factor bindingISSmolecular_function
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specifiISSmolecular_function
GO:0035556intracellular signal transductionIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005737cytoplasmISScellular_component
GO:0006816calcium ion transportIEAbiological_process
GO:0005829cytosolTAScellular_component


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