| UniProt/SwissProt ID: | NFAC1_HUMAN |
| Description: | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [Source:HGNC Symbol;Acc:7775] |
| Location: | chr18 q23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T504 | GKTVStTSHEA | RHD | PhosphoSitePlus |
| T912 | APIPVtVKREP | PhosphoSitePlus | |
| Y197 | NYSYPyASPQT | PhosphoSitePlus | |
| S526 | LLPENsMRAVI | RHD | PhosphoSitePlus |
| S245 | TSPRAsVTEES | PKCa | RegPhos |
| S294 | GSPRVsVTDDS | PKA_group | phosphoELM; RegPhos |
| S542 | LKLRNsDIELR | RHD | PhosphoSitePlus |
| S169 | AYRDPsCLSPA | PhosphoSitePlus | |
| S887 | VRRDEsPTAGP | PhosphoSitePlus | |
| Y371 | FAPEDySSFQH | PhosphoSitePlus | |
| S256 | NKRKYsLNGRQ | PRKCA | HPRD |
| S281 | GSPRVsVTDDS | PRKCA | HPRD |
| S172 | DPSCLsPASSL | PhosphoSitePlus | |
| S269 | NKRKYsLNGRQ | PRKCA | HPRD |
| S903 | VHEDGsPNLAP | PhosphoSitePlus | |
| S232 | TSPRAsVTEES | PRKCA | HPRD |
| Y426 | SHSGPyELRIE | PhosphoSitePlus | |
| S294 | GSPRVsVTDDS | PRKCA | HPRD |
| S256 | WLGARsSRPAS | PKCa | RegPhos |
| S269 | NKRKYsLNGRQ | PKCa | RegPhos |
| Y709 | EPTDDyEPAPT | PhosphoSitePlus | |
| S233 | CTLLGsPRHSP | PhosphoSitePlus; HPRD | |
| S294 | GSPRVsVTDDS | PKCa | RegPhos |
| S245 | TSPRAsVTEES | PhosphoSitePlus | |
| S294 | GSPRVsVTDDS | PhosphoSitePlus | |
| Y386 | GFCDQyLAVPQ | PhosphoSitePlus | |
| S269 | NKRKYsLNGRQ | PKA_group | phosphoELM; RegPhos |
| S117 | APALEsPRIEI | RegPhos | |
| Y394 | VPQHPyQWAKP | PhosphoSitePlus | |
| S184 | SRSCNsEASSY | PhosphoSitePlus | |
| S245 | TSPRAsVTEES | PKA_group | phosphoELM; RegPhos |
| S269 | NKRKYsLNGRQ | PhosphoSitePlus | |
| S187 | CNSEAsSYESN | PhosphoSitePlus | |
| S512 | HEAILsNTKVL | RHD | PhosphoSitePlus |
| S250 | SVTEEsWLGAR | PhosphoSitePlus | |
| S220 | CTLLGsPRHSP | HPRD | |
| S261 | SSRPAsPCNKR | PhosphoSitePlus | |
| S670 | NQRITsPVHVS | TIG | PhosphoSitePlus |
| S245 | TSPRAsVTEES | PRKCA | HPRD |
| Dephosphorylation site |
| NFAC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000253506 | A315T | BIOMART | Colorectal Cancer | 21930507, 21930502 | ENSP00000327850 | P397L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316553 | A315T | HPI | Colorectal Cancer | 16959974 | ENSP00000253506 | A315T | Sjoblom2006 | Intestines Cancer | 16959974, 21930507, 21930502 | ENSP00000327850 | T201I | COSMIC | Skin Cancer | 21984974 | ENSP00000327850 | A302T | COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| NFAC1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NFAC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | NFAC1_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | NFAC1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04360 | Axon guidance |
| hsa04380 | Osteoclast differentiation |
| hsa04310 | Wnt signaling pathway |
| hsa05166 | HTLV-I infection |
| hsa04370 | VEGF signaling pathway |
| hsa04660 | T cell receptor signaling pathway |
| hsa04662 | B cell receptor signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | ISS | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0044212 | transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0000790 | nuclear chromatin | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0048273 | mitogen-activated protein kinase p38 binding | ISS | molecular_function |
| GO:0007507 | heart development | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0001205 | RNA polymerase II distal enhancer sequence-specifi | ISS | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005528 | FK506 binding | TAS | molecular_function |
| GO:0000980 | RNA polymerase II distal enhancer sequence-specifi | ISS | molecular_function |
| GO:0001837 | epithelial to mesenchymal transition | IEA | biological_process |
| GO:0001085 | RNA polymerase II transcription factor binding | ISS | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specifi | ISS | molecular_function |
| GO:0035556 | intracellular signal transduction | IDA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005737 | cytoplasm | ISS | cellular_component |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |