| UniProt/SwissProt ID: | NET4_HUMAN |
| Description: | netrin 4 [Source:HGNC Symbol;Acc:13658] |
| Location: | chr12 q22 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T222 | EQLKItNLRVQ | Laminin_N | PhosphoSitePlus |
| Dephosphorylation site |
| NET4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000340998 | P457T | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000340998 | D381N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000340998 | F127L | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| NET4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NET4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NET4_HUMAN | UNC5A_HUMAN | ligand -> receptor | HPMR |
| NET4_HUMAN | DCC_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016322 | neuron remodeling | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0060668 | regulation of branching involved in salivary gland | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0043237 | laminin-1 binding | IEA | molecular_function |