Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NEST_HUMAN
Description:nestin [Source:HGNC Symbol;Acc:7756]
Location:chr1 q23.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S459ASTGQsPEDHAPhosphoSitePlus; HPRD
T823VKSLEtEILESPhosphoSitePlus
Y928LGKGEyQESLRPhosphoSitePlus; HPRD; phosphoELM
T456RQEAStGQSPEHPRD
T315NSRLQtPGGGSPhosphoSitePlus; phosphoELM
S891EENQEsLRSLGPhosphoSitePlus; HPRD
S768QQRRRsLGEQDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T382FLQARtPTLASPhosphoSitePlus; HPRD; phosphoELM
S1347LEAPPsEKEEGPhosphoSitePlus; HPRD
S913EVDKEsQRNLEPhosphoSitePlus
T354PVLSPtSLPSPHPRD; phosphoELM; RegPhos; SysPTM
T1589GSALKtSWAGAPhosphoSitePlus
T839QENLEtLKSPEPhosphoSitePlus; HPRD; phosphoELM
S828TEILEsLKSAGPhosphoSitePlus
S934QESLRsLEEEGPhosphoSitePlus; HPRD
S680QEPLRsPEVGDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T388PTLAStPIPPTPhosphoSitePlus; HPRD; phosphoELM
T315NSRLQtPGGGSCDC2RegPhos
S1441RWGPGsSVGSLPhosphoSitePlus; HPRD
S1418ADEEEsGEEGEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S578QECPRsLEEDLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S355VLSPTsLPSPLPhosphoSitePlus; HPRD
T776EQDQMtLRPPEPhosphoSitePlus
S1618RESWSsGED__PhosphoSitePlus
S548KETLKsLGEEIPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S484AKDGEsGGSRVPhosphoSitePlus
S1618RESWSsGEDRegPhos
S1451LQALSsSQRGEPhosphoSitePlus; HPRD
S931GEYQEsLRSLEHPRD; phosphoELM
S346GRRLGsLLPVLPhosphoSitePlus; HPRD
S820VEAVKsLETEIPhosphoSitePlus
S1175EGREEsEAEAPPhosphoSitePlus
S455QRQEAsTGQSPHPRD
S1445GSSVGsLQALSPhosphoSitePlus; HPRD
T363SPLPAtLETPVHPRD
S320TPGGGsKTSLSPhosphoSitePlus; HPRD; phosphoELM
S894QESLRsLGAWNPhosphoSitePlus
T1299TLPDStPLGFYCDK_groupphosphoELM; RegPhos
Y22RRLEAyLARVKFilamentPhosphoSitePlus
S1442WGPGSsVGSLQPhosphoSitePlus
S1571GMPLVsEGDRGHPRD; SysPTM
S471LAPPLsPDHSSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S352LLPVLsPTSLPPhosphoSitePlus; HPRD
S1496DSAEPsGSEEEPhosphoSitePlus
S702QEPLRsLEDENPhosphoSitePlus
T1299TLPDStPLGFYCDK5HPRD; RegPhos
S1489ALETEsQDSAEPhosphoSitePlus
S1502GSEEEsDPVSLPhosphoSitePlus
T338LQFPRtPEGRRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T851QAPLWtPEEINPhosphoSitePlus; HPRD; phosphoELM
S1618RESWSsGHPRD; phosphoELM
S746HKSLRsLEEQDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S465PEDHAsLAPPLHPRD
T366PATLEtPVPAFHPRD
S1492TESQDsAEPSGPhosphoSitePlus
S311LEAENsRLQTPFilamentPhosphoSitePlus
S1615EGDREsWSSGHPRD; phosphoELM
S905LENLRsPEEVDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S475LSPDHsSLEAKPhosphoSitePlus; HPRD; phosphoELM
S325SKTSLsFQDPKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T315NSRLQtPGGGSCDK_groupphosphoELM; RegPhos
S1498AEPSGsEEESDPhosphoSitePlus
T757QETLRtLEKETPhosphoSitePlus
T393TPIPPtPQAPSHPRD; phosphoELM
T315NSRLQtPGGGSCDK5HPRD; RegPhos
S831LESLKsAGQENPhosphoSitePlus
S965ELAQEsPPGMAPhosphoSitePlus; HPRD
S1016EGHPEsPEPKEPhosphoSitePlus; HPRD
S358PTSLPsPLPATPhosphoSitePlus; HPRD
T304VATYRtLLEAEHPRD
S638QELMKsLEGNLPhosphoSitePlus
S311LEAENsRLQTPHPRD; phosphoELM
S814SLKEEsVEAVKPhosphoSitePlus
T384QARTPtLASTPPhosphoSitePlus; HPRD; phosphoELM
S1409DRDGEsDGFADPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1450SLQALsSSQRGPhosphoSitePlus; HPRD
S842LETLKsPETQAPhosphoSitePlus; HPRD; phosphoELM
S1286ESREEsEEDELPhosphoSitePlus; HPRD; RegPhos
S1617DRESWsSGED_PhosphoSitePlus
S1617DRESWsSGEDRegPhos
S1577EGDRGsPFQEEPhosphoSitePlus
S1615EGDREsWSSGEPhosphoSitePlus
S398TPQAPsPAVDAPhosphoSitePlus; HPRD; phosphoELM
S588LETLKsLEKENPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T545PLEKEtLKSLGHPRD; phosphoELM
S1585QEEEGsALKTSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S790LEPLKsLDQEIPhosphoSitePlus
S564TLENQsHETLEPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S491GSRVFsICRGEPhosphoSitePlus
T315NSRLQtPGGGSCDK1HPRD
S387TPTLAsTPIPPHPRD; phosphoELM
S1617DRESWsSGHPRD; phosphoELM
T845LKSPEtQAPLWPhosphoSitePlus; HPRD; phosphoELM
S1310LRSPTsPRWDPPhosphoSitePlus
S1452QALSSsQRGEFPhosphoSitePlus; HPRD

Dephosphorylation site
NEST_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357206L1144ICOSMICOvarian Cancer21720365
ENSP00000357206G1475DCOSMICOvarian Cancer21720365
ENSP00000357206P1323SCOSMICSkin Cancer21984974
ENSP00000357206E794KCOSMICSkin Cancer21984974
ENSP00000357206P906ACOSMICOvarian Cancer21720365
ENSP00000357206Q959*COSMICSkin Cancer21984974
ENSP00000357206E676GCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000357206Breast CancerNormal vs. Cancercell lineDown0.1120198662
ENSP00000357206Breast CancerNormal vs. CancertissueDown0.5620739354

Hyperphosphorylation site
NEST_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK5_HUMANNEST_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANNEST_HUMANkinase -> substrateRegPhos
CDK1_HUMANNEST_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
NEST_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019215intermediate filament bindingISSmolecular_function
GO:0072089stem cell proliferationIMPbiological_process
GO:0000086G2/M transition of mitotic cell cycleIDAbiological_process
GO:0007417central nervous system developmentNASbiological_process
GO:0032091negative regulation of protein bindingIDAbiological_process
GO:0031076embryonic camera-type eye developmentISSbiological_process
GO:0007420brain developmentISSbiological_process
GO:0005882intermediate filamentIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:2000179positive regulation of neural precursor cell proliISSbiological_process
GO:0003674molecular_functionNDmolecular_function
GO:0005198structural molecule activityIEAmolecular_function
GO:0005882intermediate filamentNAScellular_component
GO:0030844positive regulation of intermediate filament depolISSbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:0045111intermediate filament cytoskeletonIDAcellular_component
GO:0048858cell projection morphogenesisIEAbiological_process
GO:0043086negative regulation of catalytic activityIDAbiological_process
GO:0005737cytoplasmIEAcellular_component