| UniProt/SwissProt ID: | NEO1_HUMAN |
| Description: | neogenin 1 [Source:HGNC Symbol;Acc:7754] |
| Location: | chr15 q24.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1289 | PWPIGtSMSLS | Neogenin_C | PhosphoSitePlus |
| S1299 | SDRANsTESVR | Neogenin_C | PhosphoSitePlus |
| S225 | RCVVEsGGPPK | I-set | PhosphoSitePlus |
| S1080 | LPDLGsDYKPP | Neogenin_C | PhosphoSitePlus |
| T603 | GLKKYtEYSFR | fn3 | PhosphoSitePlus |
| Y891 | TDSRYyTVRWK | fn3 | PhosphoSitePlus |
| S1294 | TSMSLsDRANS | Neogenin_C | PhosphoSitePlus |
| S1056 | TPKADsSDKMP | PhosphoSitePlus | |
| S1057 | PKADSsDKMPN | PhosphoSitePlus | |
| T1188 | PIMTDtPIPRN | Neogenin_C | PhosphoSitePlus |
| T1404 | TASIGtLGRSR | Neogenin_C | PhosphoSitePlus |
| T955 | FELVPtSPPKD | fn3 | PhosphoSitePlus |
| T51 | SIRTFtPFYFL | PhosphoSitePlus | |
| S1386 | STPLLsQQALN | Neogenin_C | PhosphoSitePlus |
| Y1279 | ARSHLyHPGSP | Neogenin_C | PhosphoSitePlus |
| Y602 | NGLKKyTEYSF | fn3 | PhosphoSitePlus |
| S1302 | ANSTEsVRNTP | Neogenin_C | PhosphoSitePlus |
| Y915 | ATTLSyLVTGL | fn3 | PhosphoSitePlus |
| Y219 | GDGGLyRCVVE | I-set | PhosphoSitePlus |
| T1300 | DRANStESVRN | Neogenin_C | PhosphoSitePlus |
| T1382 | PALPStPLLSQ | Neogenin_C | PhosphoSitePlus |
| S1066 | PNDQAsGSGGK | PhosphoSitePlus | |
| S1292 | IGTSMsLSDRA | Neogenin_C | PhosphoSitePlus |
| S1194 | PIPRNsQDITP | Neogenin_C | PhosphoSitePlus |
| S956 | ELVPTsPPKDV | fn3 | PhosphoSitePlus |
| S1220 | YRGHEsEDSMS | Neogenin_C | PhosphoSitePlus |
| Y1436 | DSESSyEPDEL | Neogenin_C | PhosphoSitePlus |
| S1068 | DQASGsGGKGS | PhosphoSitePlus | |
| S1435 | EDSESsYEPDE | Neogenin_C | PhosphoSitePlus |
| Y164 | EPSSVyAGNNA | I-set | PhosphoSitePlus |
| Y1082 | DLGSDyKPPMS | Neogenin_C | PhosphoSitePlus |
| S1214 | HQRRNsYRGHE | Neogenin_C | PhosphoSitePlus |
| Dephosphorylation site |
| NEO1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261908 | P1076R | COSMIC | Pancreatic Cancer | ENSP00000261908 | K1137* | COSMIC | Central Nervous System Neoplasms | 21817013 | ENSP00000261908 | D1176N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000341198 | D1176N | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000261908 | Prostate Cancer | Treatment (androgen-starved vs. androgen-stimulated) | cell line | Up | 2.3 | 14729644 |
| Hyperphosphorylation site |
| NEO1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RGMA_HUMAN | NEO1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04514 | Cell adhesion molecules (CAMs) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007520 | myoblast fusion | IEA | biological_process |
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0051149 | positive regulation of muscle cell differentiation | TAS | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0045296 | cadherin binding | IEA | molecular_function |
| GO:0055072 | iron ion homeostasis | IGI | biological_process |
| GO:0042692 | muscle cell differentiation | TAS | biological_process |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |