Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NELFA_HUMAN
Description:negative elongation factor complex member A [Source:HGNC Symbol;Acc:12768]
Location:chr4 p16.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S225QAPFRsPTAPSPhosphoSitePlus
S371PPEEPsAPSPTHPRD
T157LAGPLtPPVKHPhosphoSitePlus
S349PPAPSsREASRPhosphoSitePlus
Y300NATPDyAAGLVPhosphoSitePlus
S348TPPAPsSREASPhosphoSitePlus
T343IPSSEtPPAPSPhosphoSitePlus
S9QRRALsPKMASHPRD
S336VVPASsYIPSSPhosphoSitePlus
T297VVENAtPDYAAPhosphoSitePlus
S236QAPFRsPTAPSHPRD
S241SPTAPsVFSPTHPRD
T178LAGPLtPPVKHphosphoELM; SysPTM
S335SVVPAsSYIPSPhosphoSitePlus
T376SAPSPtLPAQFHPRD
S244APSVFsPTGNRHPRD
T291PAKEEtVVENAPhosphoSitePlus
S374EPSAPsPTLPAHPRD
T235SVFSPtGNRTPPhosphoSitePlus
S233APSVFsPTGNRPhosphoSitePlus
T227PFRSPtAPSVFPhosphoSitePlus
T328SYLPStPSVVPPhosphoSitePlus
T365SAPSPtLPAQFPhosphoSitePlus
T277KRRRKtLDAEVPhosphoSitePlus
T238PFRSPtAPSVFHPRD
T60KLLLGtLHLPRPhosphoSitePlus
T239PTGNRtPIPPSPhosphoSitePlus
T168LAGPLtPPVKHHPRD
S363EPSAPsPTLPAPhosphoSitePlus
T246SVFSPtGNRTPHPRD
S254APSVFsPTGNRphosphoELM
T288KRRRKtLDAEVHPRD
S360PPEEPsAPSPTPhosphoSitePlus
S384EASRPPEEPSAPSPTLPAQFKSysPTM 2.0
S384EASRPPEEPSAPSPTLPAQFKSysPTM 2.0
T386EASRPPEEPSAPSPTLPAQFKSysPTM 2.0

Dephosphorylation site
NELFA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000399165*529WCOSMICMelanoma21499247
ENSP00000399165K429NBIOMARTBreast Cancer21930507, 21930502
ENSP00000372335K440NBIOMARTBreast Cancer21930507, 21930502
ENSP00000399165*529WCOSMICMelanoma21499247

Differential expressed protein
NELFA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NELFA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ST17A_HUMANNELFA_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NELFA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0032021NELF complexIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0003682chromatin bindingIEAmolecular_function
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0034244negative regulation of transcription elongation frIEAbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0003746translation elongation factor activityIEAmolecular_function


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