| UniProt/SwissProt ID: | NELFA_HUMAN |
| Description: | negative elongation factor complex member A [Source:HGNC Symbol;Acc:12768] |
| Location: | chr4 p16.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S225 | QAPFRsPTAPS | PhosphoSitePlus | |
| S371 | PPEEPsAPSPT | HPRD | |
| T157 | LAGPLtPPVKH | PhosphoSitePlus | |
| S349 | PPAPSsREASR | PhosphoSitePlus | |
| Y300 | NATPDyAAGLV | PhosphoSitePlus | |
| S348 | TPPAPsSREAS | PhosphoSitePlus | |
| T343 | IPSSEtPPAPS | PhosphoSitePlus | |
| S9 | QRRALsPKMAS | HPRD | |
| S336 | VVPASsYIPSS | PhosphoSitePlus | |
| T297 | VVENAtPDYAA | PhosphoSitePlus | |
| S236 | QAPFRsPTAPS | HPRD | |
| S241 | SPTAPsVFSPT | HPRD | |
| T178 | LAGPLtPPVKH | phosphoELM; SysPTM | |
| S335 | SVVPAsSYIPS | PhosphoSitePlus | |
| T376 | SAPSPtLPAQF | HPRD | |
| S244 | APSVFsPTGNR | HPRD | |
| T291 | PAKEEtVVENA | PhosphoSitePlus | |
| S374 | EPSAPsPTLPA | HPRD | |
| T235 | SVFSPtGNRTP | PhosphoSitePlus | |
| S233 | APSVFsPTGNR | PhosphoSitePlus | |
| T227 | PFRSPtAPSVF | PhosphoSitePlus | |
| T328 | SYLPStPSVVP | PhosphoSitePlus | |
| T365 | SAPSPtLPAQF | PhosphoSitePlus | |
| T277 | KRRRKtLDAEV | PhosphoSitePlus | |
| T238 | PFRSPtAPSVF | HPRD | |
| T60 | KLLLGtLHLPR | PhosphoSitePlus | |
| T239 | PTGNRtPIPPS | PhosphoSitePlus | |
| T168 | LAGPLtPPVKH | HPRD | |
| S363 | EPSAPsPTLPA | PhosphoSitePlus | |
| T246 | SVFSPtGNRTP | HPRD | |
| S254 | APSVFsPTGNR | phosphoELM | |
| T288 | KRRRKtLDAEV | HPRD | |
| S360 | PPEEPsAPSPT | PhosphoSitePlus | |
| S384 | EASRPPEEPSAPSPTLPAQFK | SysPTM 2.0 | |
| S384 | EASRPPEEPSAPSPTLPAQFK | SysPTM 2.0 | |
| T386 | EASRPPEEPSAPSPTLPAQFK | SysPTM 2.0 | |
| Dephosphorylation site |
| NELFA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000399165 | *529W | COSMIC | Melanoma | 21499247 | ENSP00000399165 | K429N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000372335 | K440N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000399165 | *529W | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| NELFA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NELFA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | NELFA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NELFA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0032021 | NELF complex | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0006368 | transcription elongation from RNA polymerase II pr | TAS | biological_process |
| GO:0034244 | negative regulation of transcription elongation fr | IEA | biological_process |
| GO:0007275 | multicellular organismal development | TAS | biological_process |
| GO:0050434 | positive regulation of viral transcription | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0003746 | translation elongation factor activity | IEA | molecular_function |