Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NED4L_HUMAN
Description:neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:7728]
Location:chr18 q21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T367RARSStVTGGEPKA_groupphosphoELM
S428RPRSLsSPTVTSGK1HPRD
S335IQREPsSRLRSPhosphoSitePlus
S448RPRSLsSPTVTPKA_groupphosphoELM; RegPhos; SysPTM
S483QSPQPsPYNSPPhosphoSitePlus; phosphoELM; RegPhos
Y660EKGLDyGGVARPhosphoSitePlus
S467PSPYNsPKPQHHPRD
S459LSNPQsPQPSPHPRD
Y380TPSVAyVHTTPPhosphoSitePlus
S303PGSRTsPQELSPhosphoSitePlus
S426IRRPRsLSSPTHPRD
S479LSNPQsPQPSPPhosphoSitePlus; phosphoELM; RegPhos
T367RARSStVTGGEPhosphoSitePlus
S429PRSLSsPTVTLHPRD
T383VAYVHtTPGLPPhosphoSitePlus
T473RAVKDtLSNPQPhosphoSitePlus
S464EGAKDsPVRRAPhosphoSitePlus; phosphoELM
S428DGASGsATNSNPhosphoSitePlus
S365AGRARsSTVTGPhosphoSitePlus
S463QSPQPsPYNSPHPRD
T344RSCSVtDAVAEPhosphoSitePlus
S795LKPNGsEIMVTHECTPhosphoSitePlus
S446IRRPRsLSSPTPhosphoSitePlus; phosphoELM; RegPhos
S455VKDTLsNPQSPHPRD
S342RLRSCsVTDAVPhosphoSitePlus; phosphoELM
T367RARSStVTGGESGK_groupphosphoELM; RegPhos
S475VKDTLsNPQSPPhosphoSitePlus
T431SLSSPtVTLSAHPRD
S448RPRSLsSPTVTSGK1RegPhos; SysPTM
S342RLRSCsVTDAVSGK1HPRD; RegPhos
S366GRARSsTVTGGPhosphoSitePlus
T453RAVKDtLSNPQHPRD
T451SLSSPtVTLSAphosphoELM
T367RARSStVTGGESGK1RegPhos
T302SPGSRtSPQELHPRD; phosphoELM; RegPhos
S340SSRLRsCSVTDPhosphoSitePlus
S428RPRSLsSPTVTHPRD
T318RRLQItPDSNGPhosphoSitePlus; HPRD; phosphoELM
S444EGAKDsPVRRAHPRD
S377EEPTPsVAYVHPhosphoSitePlus
S487PSPYNsPKPQHPhosphoSitePlus; phosphoELM; RegPhos
S428DGASGsATNSNSGK1RegPhos
S336QREPSsRLRSCPhosphoSitePlus
Y485PQPSPyNSPKPPhosphoSitePlus
S342RLRSCsVTDAVSGK_groupphosphoELM; RegPhos
S342RLRSCsVTDAVPKA_groupphosphoELM; RegPhos
S448RPRSLsSPTVTPhosphoSitePlus; phosphoELM; SysPTM
S449PRSLSsPTVTLPhosphoSitePlus; phosphoELM; RegPhos
S448RPRSLsSPTVTSGK_groupphosphoELM; RegPhos; SysPTM

Dephosphorylation site
NED4L_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000372301R875HCOSMICLung Cancer20668451
ENSP00000372301G173RCOSMICLung Cancer20668451
ENSP00000372301T63KCOSMICOvarian Cancer21720365
ENSP00000256830N205DBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000372301S342ICOSMICLung Cancer20668451
ENSP00000372301V110ECOSMICLung Cancer20668451

Differential expressed protein
NED4L_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NED4L_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SGK1_HUMANNED4L_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANNED4L_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis
hsa04144Endocytosis
hsa04960Aldosterone-regulated sodium reabsorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043162ubiquitin-dependent protein catabolic process via IEAbiological_process
GO:0042176regulation of protein catabolic processNASbiological_process
GO:0005634nucleusIBAcellular_component
GO:0042391regulation of membrane potentialIDAbiological_process
GO:0016567protein ubiquitinationNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0042787protein ubiquitination involved in ubiquitin-depenIBAbiological_process
GO:0006814sodium ion transportNASbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0006883cellular sodium ion homeostasisNASbiological_process
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0006464cellular protein modification processIEAbiological_process
GO:0017080sodium channel regulator activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0045807positive regulation of endocytosisNASbiological_process
GO:0019871sodium channel inhibitor activityIEAmolecular_function
GO:2001259positive regulation of cation channel activityIEAbiological_process
GO:0010038response to metal ionIDAbiological_process
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0005622intracellularICcellular_component
GO:0005829cytosolTAScellular_component
GO:0003085negative regulation of systemic arterial blood preIEAbiological_process
GO:0004842ubiquitin-protein ligase activityIBAmolecular_function
GO:0030104water homeostasisNASbiological_process
GO:1901016regulation of potassium ion transmembrane transporIDAbiological_process
GO:0010765positive regulation of sodium ion transportIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0005737cytoplasmIBAcellular_component
GO:0034765regulation of ion transmembrane transportIDAbiological_process
GO:0010467gene expressionTASbiological_process
GO:2000810regulation of tight junction assemblyIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0007588excretionNASbiological_process
GO:0009651response to salt stressIEAbiological_process
GO:0010766negative regulation of sodium ion transportIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process