| UniProt/SwissProt ID: | NDKA_HUMAN |
| Description: | NME/NM23 nucleoside diphosphate kinase 1 [Source:HGNC Symbol;Acc:7849] |
| Location: | chr17 q21.33 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S124 | TNPADsKPGTI | HPRD | |
| T94 | VMLGEtNPADS | NDK | PhosphoSitePlus; SysPTM |
| Y67 | AGLVKyMHSGP | NDK; PSI_PsaJ | PhosphoSitePlus |
| S147 | IHGSDsVESAE | NME1 | HPRD |
| S120 | NIIHGsDSVES | NME1 | HPRD |
| S44 | KFMQAsEDLLK | NDK | PhosphoSitePlus |
| S99 | TNPADsKPGTI | HPRD | |
| H118 | GRNIIhGSDSV | NDK | PhosphoSitePlus |
| Y52 | LLKEHyVDLKD | NDK | PhosphoSitePlus |
| S120 | NIIHGsDSVES | phosphoELM | |
| T119 | VMLGEtNPADS | HPRD | |
| S122 | IHGSDsVESAE | phosphoELM | |
| S69 | KFMQAsEDLLK | NME1 | HPRD |
| S44 | KFMQAsEDLLK | NME1 | HPRD |
| S44 | KFMQAsEDLLK | phosphoELM | |
| S120 | NIIHGsDSVES | NDK | PhosphoSitePlus |
| S145 | NIIHGsDSVES | NME1 | HPRD |
| T94 | VMLGEtNPADS | HPRD; phosphoELM; SysPTM | |
| S150 | SDSVEsAEKEI | NME1 | HPRD |
| S125 | SDSVEsAEKEI | NME1 | HPRD |
| S122 | IHGSDsVESAE | NDK | PhosphoSitePlus |
| S122 | IHGSDsVESAE | NME1 | HPRD |
| S99 | TNPADsKPGTI | NDK | PhosphoSitePlus |
| S125 | SDSVEsAEKEI | phosphoELM | |
| Dephosphorylation site |
| NDKA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| NDKA_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000013034 | colorectal cancer | Normal vs. Cancer | tissue | Up | 1.9 | 14997500 | ENSP00000013034 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 3.5 | 15759316 | ENSP00000013034 | Leukemia | Normal vs. Cancer | cell line | Down | 0.29 | 17022645 | ENSP00000013034 | Leukemia | Normal vs. Cancer | cell line | Up | 2.4 | 17022645 | ENSP00000013034 | follicular thyroid carcinoma | Normal vs. Cancer | tissue | Up | 1.6 | 18316623 | ENSP00000013034 | Breast Cancer | Treatment (none vs. multidrug resistant) | cell line | Down | 0.59 | 16540677 | ENSP00000013034 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 4.2 | 14654528 | ENSP00000013034 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 4.2 | 14654528 | ENSP00000013034 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Up | 4.2 | 14654528 | ENSP00000013034 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 2 | 16097030 | ENSP00000013034 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 2.1 | 17671684 | ENSP00000013034 | Non-small cell lung carcinoma | Normal vs. Cancer | cell line | Up | 15359725 | ENSP00000013034 | Neoplasms by Histologic Type | Cancer vs. Cancer | cell line | Up | 15750928 | ENSP00000013034 | Neoplasms by Histologic Type | Cancer vs. Cancer | cell line | Up | 15750928 | ENSP00000013034 | Lung Cancer | Treatment (none vs. Mitoxantrone resistance) | cell line | Down | 0.69 | 17593620 | ENSP00000013034 | Gastric Cancer | Normal vs. Cancer | tissue | Up | 15559763 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.54 | 20052998 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.1 | 20052998 | ENSP00000013034 | Breast Cancer | Metastasis | cell line | Up | 2 | 20052998 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20543960 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20543960 | ENSP00000013034 | Neoplasms by Histologic Type | Cancer vs. Cancer (ER- vs ER+) | tissue | Up | 3.3 | 20602252 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.66 | 20739354 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | tissue | Up | 0.66 | 20739354 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | tissue | Up | 1.8 | 20857901 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.23 | 20857901 | ENSP00000013034 | Breast Cancer | Normal vs. Cancer | tissue | Up | 7.8 | 20857901 | ENSP00000013034 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 21 hour) | cell line | Up | 2.4 | 15169874 | ENSP00000013034 | Gastric Cancer | Normal vs. Cancer | tissue | Up | 20677338 | ENSP00000013034 | pancreatic ductal adenocarcinoma | Normal vs. Cancer | tissue | Up | 17492507 |
| Hyperphosphorylation site |
| NDKA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NDKA_HUMAN | NDKA_HUMAN | kinase -> substrate | HPRD |
| NDKA_HUMAN | CNKR1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00240 | Pyrimidine metabolism |
| hsa00230 | Purine metabolism |
| hsa01100 | Metabolic pathways |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0033574 | response to testosterone stimulus | IEA | biological_process |
| GO:0014075 | response to amine stimulus | IEA | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006897 | endocytosis | IEA | biological_process |
| GO:0005813 | centrosome | IEA | cellular_component |
| GO:0010629 | negative regulation of gene expression | IEA | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0003697 | single-stranded DNA binding | IEA | molecular_function |
| GO:0010976 | positive regulation of neuron projection developme | IEA | biological_process |
| GO:0043015 | gamma-tubulin binding | IEA | molecular_function |
| GO:0071333 | cellular response to glucose stimulus | IEA | biological_process |
| GO:0021766 | hippocampus development | IEA | biological_process |
| GO:0004536 | deoxyribonuclease activity | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IDA | molecular_function |
| GO:0015949 | nucleobase-containing small molecule interconversi | TAS | biological_process |
| GO:0004550 | nucleoside diphosphate kinase activity | IEA | molecular_function |
| GO:0004550 | nucleoside diphosphate kinase activity | IDA | molecular_function |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0002762 | negative regulation of myeloid leukocyte different | IEA | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0006241 | CTP biosynthetic process | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0050679 | positive regulation of epithelial cell proliferati | IMP | biological_process |
| GO:0019215 | intermediate filament binding | IEA | molecular_function |
| GO:0019899 | enzyme binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0006165 | nucleoside diphosphate phosphorylation | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0043388 | positive regulation of DNA binding | IDA | biological_process |
| GO:0006228 | UTP biosynthetic process | IEA | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0035690 | cellular response to drug | IEA | biological_process |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0042981 | regulation of apoptotic process | TAS | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007595 | lactation | IEA | biological_process |
| GO:0055086 | nucleobase-containing small molecule metabolic pro | TAS | biological_process |
| GO:0006183 | GTP biosynthetic process | IEA | biological_process |
| GO:0030879 | mammary gland development | IEA | biological_process |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0051591 | response to cAMP | IEA | biological_process |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0071398 | cellular response to fatty acid | IEA | biological_process |
| GO:0000977 | RNA polymerase II regulatory region sequence-speci | IEA | molecular_function |