Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NCOA3_HUMAN
Description:nuclear receptor coactivator 3 [Source:HGNC Symbol;Acc:7670]
Location:chr20 q13.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1114GLYGQtYPAQGPhosphoSitePlus
S867VSVGSsPPVKNMAPK14HPRD
S867VSVGSsPPVKNp38aRegPhos
S857YNRAVsLDSPVCHUKHPRD
S505VAGVHsPMASSp38aRegPhos
S429TTGQMsGARYGHPRD
S866PVSVGsSPPVKHPRD
S551PKLDNsPNMNIPhosphoSitePlus; HPRD; phosphoELM
S1062LHTLLsNTDATNuc_rec_co-actPhosphoSitePlus
S1330FGRVSsPPNAMPhosphoSitePlus; HPRD; phosphoELM
S1033PLLRNsLDDLVPhosphoSitePlus
S860AVSLDsPVSVGp38aRegPhos
S284NIDTNsLRSSMPhosphoSitePlus; HPRD
T24KLPCDtPGQGLPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S102KADVSsTGQGVPhosphoSitePlus
S505VAGVHsPMASSMAPK14HPRD
S863LDSPVsVGSSPHPRD
S857YNRAVsLDSPVIKBKBHPRD
S857YNRAVsLDSPVIKKaRegPhos
S860AVSLDsPVSVGPhosphoSitePlus; phosphoELM; RegPhos
T1067SNTDAtGLEEINuc_rec_co-actPhosphoSitePlus
S601KESKEsSVEGAPhosphoSitePlus
S860AVSLDsPVSVGMAPK14HPRD
S505VAGVHsPMASSPhosphoSitePlus; phosphoELM; RegPhos
S288NSLRSsMRPGFPhosphoSitePlus; HPRD
S694LQNGNsPAEVASRC-1PhosphoSitePlus
S1042LVGPPsNLEGQPhosphoSitePlus
S214EDINAsPEMRQPhosphoSitePlus; HPRD; phosphoELM
T1059LDQLHtLLSNTNuc_rec_co-actPhosphoSitePlus
S101QKADVsSTGQGPhosphoSitePlus
Y1357QAASIyQSSEMPhosphoSitePlus
S543LSTLSsPGPKLMAPK14HPRD
S287TNSLRsSMRPGPhosphoSitePlus; HPRD
S244GEDLQsCMICVPhosphoSitePlus
T1064TLLSNtDATGLNuc_rec_co-actPhosphoSitePlus
S694LQNGNsPAEVAHPRD
S543LSTLSsPGPKLp38aRegPhos
S728KQEQLsPKKKEPhosphoSitePlus; HPRD; phosphoELM
S509HSPMAsSGNTGPhosphoSitePlus
T184NGVSWtNETQRPASPhosphoSitePlus
S867VSVGSsPPVKNPhosphoSitePlus; phosphoELM; RegPhos
S274TRHDLsGKVVNPhosphoSitePlus; HPRD
S1329AFGRVsSPPNAHPRD
S1326FGRVSsPPNAMHPRD
S1325AFGRVsSPPNAHPRD
S543LSTLSsPGPKLPhosphoSitePlus; phosphoELM; RegPhos
T282VVNIDtNSLRSPhosphoSitePlus; HPRD
S1048NLEGQsDERALNuc_rec_co-actPhosphoSitePlus
S857YNRAVsLDSPVIKKbRegPhos
S857YNRAVsLDSPVPhosphoSitePlus; phosphoELM; RegPhos

Dephosphorylation site
NCOA3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361066D359VCOSMICOvarian Cancer21720365
ENSP00000361066M891ICOSMICMelanoma
ENSP00000361073L741PBIOMARTBreast Cancer21930507, 21930502
ENSP00000361065L751PBIOMARTBreast Cancer21930507, 21930502
ENSP00000361066D566YCOSMICOvarian Cancer21720365
ENSP00000361066P499LCOSMICLung Cancer
ENSP00000361066Q726HBIOMARTBreast Cancer21930507, 21930502
ENSP00000361065Q736HBIOMARTBreast Cancer21930507, 21930502
ENSP00000361066L741PBIOMARTBreast Cancer21930507, 21930502
ENSP00000361066P1198RCOSMICOvarian Cancer21720365
ENSP00000361073Q726HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
NCOA3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NCOA3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IKKB_HUMANNCOA3_HUMANkinase -> substrateHPRD
IKKA_HUMANNCOA3_HUMANkinase -> substrateHPRD
ZAGL2_HUMANNCOA3_HUMANkinase -> substrateRegPhos
MK14_HUMANNCOA3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
NCOA3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2001141regulation of RNA biosynthetic processIMPbiological_process
GO:0046966thyroid hormone receptor bindingNASmolecular_function
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0035257nuclear hormone receptor bindingIDAmolecular_function
GO:0048589developmental growthIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0050681androgen receptor bindingNASmolecular_function
GO:0035264multicellular organism growthIEAbiological_process
GO:0060068vagina developmentIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0010628positive regulation of gene expressionIMPbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0045618positive regulation of keratinocyte differentiatioIMPbiological_process
GO:0035624receptor transactivationTASbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0016922ligand-dependent nuclear receptor bindingIPImolecular_function
GO:0016573histone acetylationIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0003713transcription coactivator activityNASmolecular_function
GO:0060744mammary gland branching involved in thelarcheIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0004402histone acetyltransferase activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process