Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NCOA1_HUMAN
Description:nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:7668]
Location:chr2 p23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1033PRGAFsPGMGMPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S569MSSQNsPSRLNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T26GSPCDtLASSTHLHPhosphoSitePlus
S393PSVNPsISPAHPhosphoSitePlus
T209PDEPGtENQEAPhosphoSitePlus; HPRD
S1279ASGYQsPDMKAPhosphoSitePlus
T1271SLLQQtPPASGPhosphoSitePlus
S558GFSASsPVLRQPhosphoSitePlus
S1185PPASTsPFSQLHPRD; RegPhos
S1185PPASTsPFSQLDUF1518PhosphoSitePlus
S1006TANLPsPFQGMPhosphoSitePlus
S517ISTLSsPVGMTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S22HKRKGsPCDTLPhosphoSitePlus; HPRD
T684SHSSLtERHKIHPRD
S369IDREHsGLSPQPhosphoSitePlus
T1179GTNPGtPPASTHPRD; RegPhos
S274TGKIIsIDTSSPhosphoSitePlus
S395VNPSIsPAHGVMAPK1HPRD; phosphoELM
S664SCTGTsNSASAHPRD
T277IISIDtSSLRAPhosphoSitePlus
T789CNTNPtPMTKPPhosphoSitePlus
S1250FAPSLsPGSSMDUF1518PhosphoSitePlus
S997SQPYSsPSPTAPhosphoSitePlus
S395VNPSIsPAHGVErk2(MAPK1RegPhos
T1026MPVQVtPPRGAPhosphoSitePlus
T1179GTNPGtPPASTDUF1518PhosphoSitePlus
T1179GTNPGtPPASTMAPK1HPRD; phosphoELM
T1179GTNPGtPPASTMAPK3phosphoELM
S488LAQFMsPRRQVPhosphoSitePlus
T663LSCTGtSNSASHPRD
S325RGTASsPSYRFPhosphoSitePlus
S372EHSGLsPQDDTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T979PPQQAtPPLIMPhosphoSitePlus
S1185PPASTsPFSQLMAPK3phosphoELM
S1185PPASTsPFSQLMAPK1HPRD; phosphoELM
S659CKDVLsCTGTSHPRD
S565VLRQMsSQNSPPhosphoSitePlus; HPRD
T1179GTNPGtPPASTMAPKAPK2RegPhos
S395VNPSIsPAHGVPhosphoSitePlus; RegPhos
S389PRVNPsVNPSIPhosphoSitePlus
S582PAKAEsKDNKEPhosphoSitePlus; HPRD
S395VNPSIsPAHGVErk2RegPhos
T1179GTNPGtPPASTErk2RegPhos
S2LGDSHPRD
S1185PPASTsPFSQLErk2RegPhos
S103DISSSsQGVIEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S681CPSSHsSLTERHPRD
T661DVLSCtGTSNSHPRD
S566LRQMSsQNSPSPhosphoSitePlus; HPRD
S659CKDVLsCTGTSSRC-1PhosphoSitePlus
S1185PPASTsPFSQLMAPKAPK2RegPhos
T1426TSGPQtPQAQQPhosphoSitePlus

Dephosphorylation site
NCOA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000320940R1073WCOSMICMelanoma21499247
ENSP00000320940P356LTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000288599Q303EBIOMARTBreast Cancer21930507, 21930502
ENSP00000385216G131WCOSMICOvarian Cancer21720365
ENSP00000385097Q303EBIOMARTBreast Cancer21930507, 21930502
ENSP00000379197Q303EBIOMARTBreast Cancer21930507, 21930502
ENSP00000385097E1391DBIOMARTBreast Cancer21930507, 21930502
ENSP00000320940G131WCOSMICOvarian Cancer21720365
ENSP00000288599E1391DBIOMARTBreast Cancer21930507, 21930502
ENSP00000385216P356LTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000385216Q303EBIOMARTBreast Cancer21930507, 21930502
ENSP00000320940Q303EBIOMARTBreast Cancer21930507, 21930502
ENSP00000385216R1073WCOSMICMelanoma21499247

Differential expressed protein
NCOA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NCOA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNCOA1_HUMANkinase -> substrateRegPhos
MK01_HUMANNCOA1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MAPK2_HUMANNCOA1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
NCOA1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:2001038regulation of cellular response to drugIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0043967histone H4 acetylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0000435positive regulation of transcription from RNA polyIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0035257nuclear hormone receptor bindingIDAmolecular_function
GO:0046983protein dimerization activityIEAmolecular_function
GO:0030374ligand-dependent nuclear receptor transcription coIDAmolecular_function
GO:0016922ligand-dependent nuclear receptor bindingIPImolecular_function
GO:0004871signal transducer activityIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0003713transcription coactivator activityIEAmolecular_function
GO:0001105RNA polymerase II transcription coactivator activiNASmolecular_function
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:2001141regulation of RNA biosynthetic processIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function
GO:0006351transcription, DNA-dependentIDAbiological_process
GO:0035257nuclear hormone receptor bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0004402histone acetyltransferase activityIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0000435positive regulation of transcription from RNA polyIDAbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyNASbiological_process