| UniProt/SwissProt ID: | N2DL2_HUMAN |
| Description: | UL16 binding protein 2 [Source:HGNC Symbol;Acc:14894] |
| Location: | chr6 q25.1 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T60 | QVDEKtFLHYD | MHC_I | PhosphoSitePlus |
| Y64 | KTFLHyDCGNK | MHC_I | PhosphoSitePlus |
| Dephosphorylation site |
| N2DL2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356320 | S186* | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| N2DL2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| N2DL2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| N2DL2_HUMAN | NKG2D_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0031225 | anchored to membrane | IEA | cellular_component |
| GO:0019882 | antigen processing and presentation | IEA | biological_process |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0016020 | membrane | NAS | cellular_component |
| GO:0032393 | MHC class I receptor activity | NAS | molecular_function |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0030101 | natural killer cell activation | NAS | biological_process |
| GO:0042612 | MHC class I protein complex | IEA | cellular_component |