Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYH9_HUMAN
Description:myosin, heavy chain 9, non-muscle [Source:HGNC Symbol;Acc:7579]
Location:chr22 q12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T725RYEILtPNSIPHPRD
Y754LDSNLyRIGQSHPRD; phosphoELM; RegPhos
T725RYEILtPNSIPMyosin_headPhosphoSitePlus
S1916NREVSsLKNKLMyosin_tail_1; AAA_13PhosphoSitePlus
T1151TELEDtLDSTAMyosin_tail_1PhosphoSitePlus
S1480ETKALsLARALHPRD
T638PGAFKtRKGMFMyosin_headPhosphoSitePlus
Y1861RNAEQyKDQADMyosin_tail_1; AAA_13PhosphoSitePlus
T181SGAGKtENTKKRegPhos
S196LAYVAsSHKSKMyosin_headPhosphoSitePlus
T226FGNAKtVKNDNMyosin_headPhosphoSitePlus
S1714EIANSsGKGALHPRD; SysPTM
S876METLQsQLMAEMyosin_tail_1PhosphoSitePlus
S1519DDVGKsVHELEMyosin_tail_1; CALCOCO1; PhosphoSitePlus
T391TRGILtPRIKVMyosin_headPhosphoSitePlus
Y151MPPHIyAITDTMyosin_headPhosphoSitePlus
Y1408EKVAAyDKLEKHPRD; phosphoELM
S1480ETKALsLARALMyosin_tail_1; CALCOCO1; PhosphoSitePlus
S36LVWVPsDKSGFMyosin_NPhosphoSitePlus
T1800QEMEGtVKSKYChak1phosphoELM
S1808SKYKAsITALEMyosin_tail_1; AAA_13PhosphoSitePlus
S1511MEDLMsSKDDVHPRD
S751ALELDsNLYRIMyosin_headPhosphoSitePlus
S728ILTPNsIPKGFMyosin_headPhosphoSitePlus
S1628EAHIDsANKNRMyosin_tail_1; Reo_sigmaCPhosphoSitePlus
T1810YKASItALEAKMyosin_tail_1; AAA_13PhosphoSitePlus
Y193IQYLAyVASSHMyosin_headPhosphoSitePlus
Y130KNLPIySEEIVMyosin_headPhosphoSitePlus
S759YRIGQsKVFFRMyosin_headPhosphoSitePlus
S36LVWVPsDKSGFHPRD
S1803EGTVKsKYKASChak1phosphoELM
Y1460TISAKyAEERDMyosin_tail_1; CALCOCO1PhosphoSitePlus
T1329KLSLStKLKQVHPRD
T1269GERVRtELADKMyosin_tail_1PhosphoSitePlus
S1803EGTVKsKYKASMyosin_tail_1; AAA_13PhosphoSitePlus
S1915MNREVsSLKNKMyosin_tail_1; AAA_13PhosphoSitePlus
Y9QAADKyLYVDKPhosphoSitePlus
T1416LEKTKtRLQQEMyosin_tail_1; Reo_sigmaCPhosphoSitePlus
T1800QEMEGtVKSKYMyosin_tail_1; AAA_13PhosphoSitePlus
T1745EEQGNtELINDHPRD; SysPTM
T638PGAFKtRKGMFRegPhos
S1376KKMEDsVGCLEMyosin_tail_1; Reo_sigmaCPhosphoSitePlus
Y190KKVIQyLAYVAMyosin_headPhosphoSitePlus
S1916NREVSsLKNKLPKCa(PKC alphaRegPhos
S1808SKYKAsITALEChak1phosphoELM
T1906EDATEtADAMNMyosin_tail_1; AAA_13PhosphoSitePlus
T383LGINVtDFTRGMyosin_headPhosphoSitePlus
T1745EEQGNtELINDMyosin_tail_1; AAA_13PhosphoSitePlus; SysPTM
Y1408EKVAAyDKLEKMyosin_tail_1; Reo_sigmaCPhosphoSitePlus
T383LGINVtDFTRGHPRD
Y138EIVEMyKGKKRMyosin_headPhosphoSitePlus
Y400KVGRDyVQKAQMyosin_headPhosphoSitePlus
Y11ADKYLyVDKNFPhosphoSitePlus
S1916NREVSsLKNKLPKC_groupphosphoELM; RegPhos
S344LLRVIsGVLQLMyosin_headPhosphoSitePlus
S1512EDLMSsKDDVGHPRD
Y721EFRQRyEILTPMyosin_headPhosphoSitePlus
S1526HELEKsKRALEMyosin_tail_1; ADIPPhosphoSitePlus
T645KGMFRtVGQLYHPRD
T1504NKQFRtEMEDLHPRD
S1714EIANSsGKGALMyosin_tail_1; Reo_sigmaCPhosphoSitePlus; SysPTM
S1943GAGDGsDEEVDPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T1382VGCLEtAEEVKMyosin_tail_1; Reo_sigmaCPhosphoSitePlus
S1916NREVSsLKNKLPKC_alphaphosphoELM
S1713DEIANsSGKGAphosphoELM
Y754LDSNLyRIGQSMyosin_headPhosphoSitePlus

Dephosphorylation site
MYH9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000216181E286DCOSMICOvarian Cancer21720365
ENSP00000216181Q1761*COSMICMelanoma
ENSP00000216181H686YCOSMICLung Cancer
ENSP00000216181R398QCOSMICRenal Cancer20054297
ENSP00000216181F1261LCOSMICHead and Neck Cancer21798893
ENSP00000216181K810NSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000216181S1163*COSMICHead and Neck Cancer21798893
ENSP00000216181E457KCOSMICHead and Neck Cancer21798893
ENSP00000216181A800VCOSMICCentral Nervous System Neoplasms21163964
ENSP00000216181Q980*COSMICOvarian Cancer21720365
ENSP00000216181D438ECOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000216181Hepatocellular CarcinomaNormal vs. Cancercell lineUp7.418646787
ENSP00000216181Gastric CancerMetastasiscell lineDown0.4717022644
ENSP00000216181Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000216181Esophageal CancerNormal vs. CancertissueDown0.3219142970
ENSP00000216181Breast CancerNormal vs. Cancercell lineDown0.2816596714
ENSP00000216181Breast CancerNormal vs. Cancercell lineDown0.2716596714
ENSP00000216181Breast CancerNormal vs. Cancercell lineDown0.2316596714
ENSP00000216181Breast CancerNormal vs. CancertissueUp18257521
ENSP00000216181Hepatocellular CarcinomaMetastasiscell lineUp219016532
ENSP00000216181Gastric CancerMetastasiscell lineDown0.4717022644
ENSP00000216181Gastric CancerCancer vs. Cancer (good vs. proo survival)tissueDown0.3218830628
ENSP00000216181Pancreatic CancerNormal vs. CancertissueUp2.316230073
ENSP00000216181Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.420625496
ENSP00000216181Pancreatic CancerNormal vs. CancertissueUp6319199705

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y754Myosin_headLELDSNLyRIGQSKVcholangiocellular carcinoma21253578PhosphoSitePlus
Y1408Myosin_tail_1; Reo_sigmaC; CALCOCO1HEEKVAAyDKLEKTKcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANMYH9_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANMYH9_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa05416Viral myocarditis
hsa05132Salmonella infection
hsa04530Tight junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051015actin filament bindingIEAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0043234protein complexIDAcellular_component
GO:0032154cleavage furrowIDAcellular_component
GO:0001931uropodIEAcellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0000910cytokinesisIMPbiological_process
GO:0006200ATP catabolic processIDAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0030898actin-dependent ATPase activityIDAmolecular_function
GO:0000212meiotic spindle organizationIEAbiological_process
GO:0030224monocyte differentiationIEPbiological_process
GO:0005826actomyosin contractile ringIDAcellular_component
GO:0032796uropod organizationIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0016887ATPase activityIDAmolecular_function
GO:0007132meiotic metaphase IIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0031532actin cytoskeleton reorganizationIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0016460myosin II complexIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0001726ruffleIDAcellular_component
GO:0006509membrane protein ectodomain proteolysisIDAbiological_process
GO:0006928cellular component movementIEAbiological_process
GO:0008180signalosomeIDAcellular_component
GO:0005938cell cortexIEAcellular_component
GO:0001525angiogenesisIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0043534blood vessel endothelial cell migrationIMPbiological_process
GO:0008305integrin complexIDAcellular_component
GO:0000904cell morphogenesis involved in differentiationIEAbiological_process
GO:0030863cortical cytoskeletonIEAcellular_component
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0043495protein anchorIMPmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0050900leukocyte migrationNASbiological_process
GO:0016459myosin complexIEAcellular_component
GO:0030048actin filament-based movementIDAbiological_process
GO:0007520myoblast fusionIEAbiological_process
GO:0007229integrin-mediated signaling pathwayNASbiological_process
GO:0043531ADP bindingIDAmolecular_function
GO:0003779actin bindingIDAmolecular_function
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0008360regulation of cell shapeIMPbiological_process
GO:0005913cell-cell adherens junctionIEAcellular_component
GO:0031252cell leading edgeIDAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0030220platelet formationIMPbiological_process
GO:0031594neuromuscular junctionIEAcellular_component
GO:0003774motor activityIEAmolecular_function
GO:0051295establishment of meiotic spindle localizationIEAbiological_process
GO:0001772immunological synapseIEAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005819spindleIEAcellular_component
GO:0015031protein transportIMPbiological_process
GO:0001725stress fiberIDAcellular_component
GO:0004871signal transducer activityIEAmolecular_function
GO:0000146microfilament motor activityIDAmolecular_function
GO:0016337cell-cell adhesionIEAbiological_process
GO:0001768establishment of T cell polarityIEAbiological_process