| UniProt/SwissProt ID: | MYEF2_HUMAN |
| Description: | myelin expression factor 2 [Source:HGNC Symbol;Acc:17940] |
| Location: | chr15 q21.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T234 | GRLGStIFVAN | PhosphoSitePlus | |
| Y164 | ETMNKyDLSGR | RRM_1 | PhosphoSitePlus |
| S431 | QGFGDsFGRLG | PhosphoSitePlus | |
| Y317 | VPHEEyRSHDG | PhosphoSitePlus | |
| S233 | AGRLGsTIFVA | PhosphoSitePlus | |
| S17 | ATGGDsPHLQP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Dephosphorylation site |
| MYEF2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316950 | M413I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000316950 | G433C | COSMIC | Lung Cancer | 20668451 | ENSP00000316950 | D165H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000316950 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 2.6 | 19199705 |
| Hyperphosphorylation site |
| MYEF2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FRK_HUMAN | MYEF2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MYEF2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0030182 | neuron differentiation | IEP | biological_process |
| GO:0014902 | myotube differentiation | IEP | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |