Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYCB2_HUMAN
Description:MYC binding protein 2, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:23386]
Location:chr13 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1791KENVKyAVRLRPHRPhosphoSitePlus
T2645DQNSQtPPPSPPhosphoSitePlus; phosphoELM
T3040NSQQPtEEKETPhosphoSitePlus
S1586IVKQVsTENDSPhosphoSitePlus
S3256GGIGGsTWYLVPhosphoSitePlus
S1123DARLPsAADMQPhosphoSitePlus
S1472LRKILsEGVDHPhosphoSitePlus
S2281SQKKMsLQQDQFilaminPhosphoSitePlus
S4294MALADsKTMKAPhosphoSitePlus
S2882ENRAPsPHVVQPhosphoSitePlus
T4088LKAKGtTITGTPhosphoSitePlus
S3773GNKVTsMTFLTPhosphoSitePlus
Y384GYAQGyLLYRDPhosphoSitePlus
T1877LSVVStVVRASPhosphoSitePlus
S3894KALLSsPEGEEPhosphoSitePlus; phosphoELM
S2801PSGASsPRSSSPhosphoSitePlus
S2835RSKSDsYTLDPPhosphoSitePlus
Y2836SKSDSyTLDPDPhosphoSitePlus
Y1238GGRGEyTAKIKPHRPhosphoSitePlus
Y3228PGCGRyAGGQGPhosphoSitePlus
Y4507AYYVCyKCRKAPhosphoSitePlus
Y3234AGGQGyNSIGHPhosphoSitePlus
T4283EGCGRtKLFWLPhosphoSitePlus
S4177EEEFRsPVRCIPhosphoSitePlus
T1445YPVSAtGKAVVPhosphoSitePlus
S3467RRRVNsGDTEVPhosphoSitePlus; phosphoELM
S145SGESDsDEEEEPhosphoSitePlus; phosphoELM
T580EDGEStKSRRQPhosphoSitePlus
S3758NARYVsVHVDNPhosphoSitePlus
S2694STSGKsELSSKPhosphoSitePlus
S3386MRYLRsTSVPAPhosphoSitePlus; phosphoELM
T568GSIFFtGSASKPhosphoSitePlus
T4093TTITGtAGTTVPhosphoSitePlus
S4334LSAVGsVCSDAPhosphoSitePlus
S143VQSGEsDSDEEPhosphoSitePlus; phosphoELM
S2652PPSPFsVQAFNPhosphoSitePlus; phosphoELM
S129QKKEIsLAAASPhosphoSitePlus
S3084KNKVLsMLKEPPhosphoSitePlus
T4097GTAGTtVGKGVPhosphoSitePlus
S2831PPRERsKSDSYPhosphoSitePlus; phosphoELM; SysPTM
T3470VNSGDtEVGSSPhosphoSitePlus
S572FTGSAsKGEDGPhosphoSitePlus
Y3356KMPCLyLQTLAPhosphoSitePlus
Y26DSRGHyQLLLSPhosphoSitePlus
S2806SPRSSsPHDKNPhosphoSitePlus
S2805SSPRSsSPHDKPhosphoSitePlus
T4103VGKGVtTVTLPPhosphoSitePlus
S2833RERSKsDSYTLPhosphoSitePlus; phosphoELM
S2947QEMRAsPKISRPhosphoSitePlus
S2783GSRLSsPKPKTPhosphoSitePlus
S2682DRGNIsTSSKPPhosphoSitePlus
T4032VLPEVtPSRLAPhosphoSitePlus
S2774SSRAEsPGPGSPhosphoSitePlus; phosphoELM
S582GESTKsRRQSKPhosphoSitePlus
Y3756GINARyVSVHVPhosphoSitePlus
T2842TLDPDtLRKKKPhosphoSitePlus
Y1277AAREKyAMMFDPHRPhosphoSitePlus
S2749DSHSRsLSPNHPhosphoSitePlus; phosphoELM
S3440FQRSYsVVASEPhosphoSitePlus; phosphoELM
S140KNSVQsGESDSPhosphoSitePlus; phosphoELM
S3893EKALLsSPEGEPhosphoSitePlus; phosphoELM
S2698KSELSsKHSRSPhosphoSitePlus
S1876ALSVVsTVVRAPhosphoSitePlus
S579GEDGEsTKSRRPhosphoSitePlus
Y39ALADRyRRIYTPhosphoSitePlus
S3418KSMPPsLETSPPhosphoSitePlus
S2751HSRSLsPNHNTPhosphoSitePlus; phosphoELM
S2795PANRSsPSGASPhosphoSitePlus
S1443EIYPVsATGKAPhosphoSitePlus
S3489LSRLIsAHSSLPhosphoSitePlus
Y4473LMRLEyEGLHKPhosphoSitePlus
T1395HWSWTtLVLGVPhosphoSitePlus
S2649QTPPPsPFSVQPhosphoSitePlus; phosphoELM
S2779SPGPGsRLSSPPhosphoSitePlus
T4296LADSKtMKAMVPhosphoSitePlus
T3775KVTSMtFLTGKPhosphoSitePlus
Y3383QDEMRyLRSTSPhosphoSitePlus
T2690SKPAStSGKSEPhosphoSitePlus
Y1293QAGWWyVAWARPHRPhosphoSitePlus
Y4344ADCQEyAKIACPhosphoSitePlus
S2643LLDQNsQTPPPphosphoELM
S3485PSPELsRLISAPhosphoSitePlus
S3236GQGYNsIGHFCPhosphoSitePlus
S570IFFTGsASKGEPhosphoSitePlus

Dephosphorylation site
MYCB2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000349892F3976LBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000349892M4469ICOSMICOvarian Cancer21720365
ENSP00000349892R4418WBIOMARTBreast Cancer21930507, 21930502
ENSP00000444596R2780QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000349892E2964KCOSMICMelanoma21499247
ENSP00000349892M4391IBIOMARTBreast Cancer21930507, 21930502
ENSP00000349892A4183GCOSMICOvarian Cancer21720365
ENSP00000349892S262FCOSMICSkin Cancer21984974
ENSP00000349892A2936TCOSMICHead and Neck Cancer21798893
ENSP00000349892R1880QCOSMICSkin Cancer21984974
ENSP00000349892E4534KCOSMICSkin Cancer21984974
ENSP00000349892P2356SCOSMICSkin Cancer21984974

Differential expressed protein
MYCB2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MYCB2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANMYCB2_HUMANkinase -> substrateRegPhos
UHMK1_HUMANMYCB2_HUMANkinase -> substrateHPRD; RegPhos
KPCA_HUMANMYCB2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
MYCB2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048667cell morphogenesis involved in neuron differentiatIEAbiological_process
GO:0051493regulation of cytoskeleton organizationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0021785branchiomotor neuron axon guidanceIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0005488bindingIEAmolecular_function
GO:0021952central nervous system projection neuron axonogeneIEAbiological_process
GO:0015630microtubule cytoskeletonIEAcellular_component
GO:0008045motor neuron axon guidanceIEAbiological_process
GO:0032880regulation of protein localizationIEAbiological_process
GO:0016567protein ubiquitinationIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0016874ligase activityIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0030424axonIEAcellular_component


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