Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MUSK_HUMAN
Description:muscle, skeletal, receptor tyrosine kinase [Source:HGNC Symbol;Acc:7525]
Location:chr9 q31.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y755IYSADyYKANEPkinase_TyrPhosphoSitePlus
T31KAPVItTPLETI-setPhosphoSitePlus
Y756YSADYyKANENPkinase_TyrPhosphoSitePlus
T294GEKFStAKAAAI-setPhosphoSitePlus
Y751LSRNIySADYYPkinase_TyrPhosphoSitePlus
Y554HPNPMyQRMPLPhosphoSitePlus
Y577RNNIEyVRDIGPkinase_TyrPhosphoSitePlus
Y813HEEVIyYVRDGPkinase_TyrPhosphoSitePlus
S293HGEKFsTAKAAI-setPhosphoSitePlus

Dephosphorylation site
MUSK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000393608P390RBIOMARTBreast Cancer21930507, 21930502
ENSP00000363571S268*BIOMARTLung Cancer21930507, 21930502
ENSP00000363571P384RBIOMARTBreast Cancer21930507, 21930502
ENSP00000363571N819SHPILung Cancer17344846
ENSP00000189978P390RBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
MUSK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MUSK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AGRIN_HUMANMUSK_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
MUSK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008582regulation of synaptic growth at neuromuscular junISSbiological_process
GO:0046777protein autophosphorylationISSbiological_process
GO:0001934positive regulation of protein phosphorylationISSbiological_process
GO:0043113receptor clusteringIEAbiological_process
GO:0005887integral to plasma membraneISScellular_component
GO:0008582regulation of synaptic growth at neuromuscular junIEAbiological_process
GO:0045211postsynaptic membraneISScellular_component
GO:0030054cell junctionIEAcellular_component
GO:0007528neuromuscular junction developmentISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityISSmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0007613memoryISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0043525positive regulation of neuron apoptotic processIEAbiological_process
GO:0010628positive regulation of gene expressionISSbiological_process
GO:0031594neuromuscular junctionIEAcellular_component
GO:0031594neuromuscular junctionISScellular_component
GO:2000541positive regulation of protein geranylgeranylationISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0071340skeletal muscle acetylcholine-gated channel clusteISSbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0007528neuromuscular junction developmentIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process


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