| UniProt/SwissProt ID: | MTA70_HUMAN |
| Description: | methyltransferase like 3 [Source:HGNC Symbol;Acc:17563] |
| Location: | chr14 q11.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S64 | GGPKPsTASAV | HPRD; phosphoELM | |
| T356 | QELALtQSVGG | PhosphoSitePlus; HPRD; phosphoELM | |
| S219 | RKHAAsDVDLE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S43 | PEAALsPTFRS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T65 | GPKPStASAVP | HPRD; phosphoELM | |
| S243 | QSKKVsQEILE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T74 | VPELAtDPELE | HPRD | |
| S48 | SPTFRsDSPVP | PhosphoSitePlus; HPRD; phosphoELM | |
| T57 | VPTAPtSGGPK | PhosphoSitePlus; HPRD; phosphoELM | |
| S50 | TFRSDsPVPTA | PhosphoSitePlus; HPRD; phosphoELM | |
| T54 | DSPVPtAPTSG | HPRD; phosphoELM | |
| S350 | KDHTPsQELAL | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| MTA70_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000298717 | D412N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000298717 | S196C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000298717 | Q231* | COSMIC | Pancreatic Cancer | ENSP00000298717 | S315F | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| MTA70_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MTA70_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| WEE1_HUMAN | MTA70_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK3_HUMAN | MTA70_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK2_HUMAN | MTA70_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MTA70_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase | IMP | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006139 | nucleobase-containing compound metabolic process | IEA | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0001510 | RNA methylation | IMP | biological_process |
| GO:0008168 | methyltransferase activity | IEA | molecular_function |