Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MRE11_HUMAN
Description:MRE11 meiotic recombination 11 homolog A (S. cerevisiae) [Source:HGNC Symbol;Acc:7230]
Location:chr11 q21
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S688GVDFEsSEDDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S676SSKIMsQSQVSPhosphoSitePlus; HPRD
Y190PDERLyRMFVNMetallophosPhosphoSitePlus
S681SQSQVsKGVDFPhosphoSitePlus; HPRD
T74RKTLHtCLELLMetallophosPhosphoSitePlus
S619ASRNMsIIDAFPhosphoSitePlus; HPRD
S661VDFESsEDDDDHPRD
S667TDQRWsSTSSSHPRD
S670RWSSTsSSKIMHPRD
S678KIMSQsQVSKGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S653SQSQVsKGVDFHPRD
S689VDFESsEDDDDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S531ARALRsQSEESPhosphoSitePlus
S660IFPTTsKTDQRRegPhos
S382SVLRFsQKFVDMre11_DNA_bindPhosphoSitePlus
T641QRWSStSSSKIHPRD
S702FMNTSsLRRNHPRD; phosphoELM
S264QLFYIsQPGSSPhosphoSitePlus
S275VVTSLsPGEAVPhosphoSitePlus
S650KIMSQsQVSKGHPRD
S643WSSTSsSKIMSHPRD
S590ASRGGsQRGRAPhosphoSitePlus
S602TGLETsTRSRNHPRD
S183LYGLGsIPDERMetallophosPhosphoSitePlus
S668DQRWSsTSSSKHPRD
T669QRWSStSSSKIPhosphoSitePlus; HPRD
S642RWSSTsSSKIMHPRD
S672SSTSSsKIMSQPhosphoSitePlus
T634PTTSKtDQRWSHPRD
T272GSSVVtSLSPGPhosphoSitePlus
S639TDQRWsSTSSSHPRD
S649IEVDEsDVEEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S561NDSDDsISAATPhosphoSitePlus
T74RKTLHtCLELLHPRD; phosphoELM; RegPhos
S674FMNTSsLRRNHPRD
T329DNPKVtQAIQSMre11_DNA_bindPhosphoSitePlus
T426PSEGTtLRVEDMre11_DNA_bindPhosphoSitePlus
S273SSVVTsLSPGEPhosphoSitePlus
S264QLFYIsQPGSSATMHPRD; phosphoELM; RegPhos
T603GLETStRSRNSHPRD
T662PTTSKtDQRWSHPRD
T481YQLEKtQRFLKPhosphoSitePlus
S671WSSTSsSKIMSPhosphoSitePlus; HPRD
T597RGRADtGLETSPhosphoSitePlus; HPRD
S558QMANDsDDSISPhosphoSitePlus; HPRD; phosphoELM
S701PFMNTsSLRRNPhosphoSitePlus; HPRD; phosphoELM
S660GVDFEsSEDDDHPRD
S673PFMNTsSLRRNHPRD
S165EKIDIsPVLLQMetallophosPhosphoSitePlus
S621IEVDEsDVEEDHPRD
S648SSKIMsQSQVSHPRD
S640DQRWSsTSSSKHPRD

Dephosphorylation site
MRE11_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000326094F237CCOSMICBreast Cancer16959974
ENSP00000325863F237CSjoblom2006, HPIBreast Cancer16959974
ENSP00000325863R305WHPIOvarian Cancer14684699
ENSP00000326094Y190HCOSMICHead and Neck Cancer21798893
ENSP00000325863S104CHPIOther Cancer11196167
ENSP00000325863H302YSjoblom2006, HPIBreast Cancer16959974, 18428421
ENSP00000325863R572QHPIOther Cancer11196167
ENSP00000325863R503HHPIOther Cancer11196167
ENSP00000326094H302YSjoblom2006, COSMICBreast Cancer16959974, 18428421

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000325863Esophageal CancerNormal vs. CancertissueDown0.3619142970

Hyperphosphorylation site
MRE11_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ATM_HUMANMRE11_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANMRE11_HUMANkinase -> substrateRegPhos
MRE11_HUMANFACD2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03450Non-homologous end-joining
hsa03440Homologous recombination

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033674positive regulation of kinase activityIDAbiological_process
GO:0004518nuclease activityTASmolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0004527exonuclease activityIEAmolecular_function
GO:0090305nucleic acid phosphodiester bond hydrolysisTASbiological_process
GO:0000014single-stranded DNA specific endodeoxyribonucleaseTASmolecular_function
GO:00084083'-5' exonuclease activityTASmolecular_function
GO:0006259DNA metabolic processIEAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0000019regulation of mitotic recombinationTASbiological_process
GO:0032508DNA duplex unwindingIMPbiological_process
GO:0004003ATP-dependent DNA helicase activityIMPmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0032876negative regulation of DNA endoreduplicationIMPbiological_process
GO:0006281DNA repairTASbiological_process
GO:0000781chromosome, telomeric regionIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0007004telomere maintenance via telomeraseTASbiological_process
GO:0051276chromosome organizationIEAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0006303double-strand break repair via nonhomologous end jTASbiological_process
GO:0030870Mre11 complexNAScellular_component
GO:0007131reciprocal meiotic recombinationTASbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0000075cell cycle checkpointIEAbiological_process
GO:0007062sister chromatid cohesionIMPbiological_process
GO:0031954positive regulation of protein autophosphorylationIDAbiological_process
GO:0000724double-strand break repair via homologous recombinTASbiological_process
GO:0006310DNA recombinationTASbiological_process
GO:0003690double-stranded DNA bindingTASmolecular_function
GO:0007129synapsisIEAbiological_process
GO:0004520endodeoxyribonuclease activityTASmolecular_function
GO:0030145manganese ion bindingIEAmolecular_function
GO:0004519endonuclease activityIEAmolecular_function
GO:0003677DNA bindingIDAmolecular_function
GO:0006302double-strand break repairIEAbiological_process


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