Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MMP14_HUMAN
Description:matrix metallopeptidase 14 (membrane-inserted) [Source:HGNC Symbol;Acc:7160]
Location:chr14 q11.2
Node attribute:PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T140VGEYAtYEAIRPeptidase_M10PhosphoSitePlus
Y573PRRLLyCQRSLDUF3377PhosphoSitePlus
Y138PKVGEyATYEAPeptidase_M10PhosphoSitePlus
S577LYCQRsLLDKVDUF3377PhosphoSitePlus
T77YGLQVtGKADAPG_binding_1PhosphoSitePlus
T567FRRHGtPRRLLDUF3377PhosphoSitePlus
Y141GEYATyEAIRKPeptidase_M10PhosphoSitePlus

Dephosphorylation site
MMP14_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000308208V555ACOSMICMelanoma19330028
ENSP00000308208H565QCOSMICHepatocellular Carcinoma21822264
ENSP00000308208R160HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
MMP14_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MMP14_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANMMP14_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04912GnRH signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0031638zymogen activationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006979response to oxidative stressIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0030324lung developmentIEAbiological_process
GO:0004222metalloendopeptidase activityIEAmolecular_function
GO:0008237metallopeptidase activityIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0030307positive regulation of cell growthIDAbiological_process
GO:0042470melanosomeIEAcellular_component
GO:0022617extracellular matrix disassemblyTASbiological_process
GO:0048754branching morphogenesis of a tubeIEAbiological_process
GO:0043615astrocyte cell migrationIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0001503ossificationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0051895negative regulation of focal adhesion assemblyIEAbiological_process
GO:0005178integrin bindingIEAmolecular_function
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0048771tissue remodelingIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0001541ovarian follicle developmentIEAbiological_process
GO:0010952positive regulation of peptidase activityIEAbiological_process
GO:0009725response to hormone stimulusIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0030198extracellular matrix organizationTASbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0016504peptidase activator activityIEAmolecular_function
GO:0001935endothelial cell proliferationIEAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0005796Golgi lumenTAScellular_component


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