Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK04_HUMAN
Description:mitogen-activated protein kinase 4 [Source:HGNC Symbol;Acc:6878]
Location:chr18 q21.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S196TKWYRsPRLLLErk4(MAPK4RegPhos
S196TKWYRsPRLLLErk4RegPhos
S186HKGYLsEGLVTHPRD; SysPTM
S196TKWYRsPRLLLMAPK4HPRD; phosphoELM

Dephosphorylation site
MK04_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000383234P246TDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000383234R272TBIOMARTBreast Cancer21930507, 21930502
ENSP00000383234D336NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
MK04_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MK04_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK04_HUMANMK04_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
MK04_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0000165MAPK cascadeTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004707MAP kinase activityIEAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function


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