| UniProt/SwissProt ID: | MK04_HUMAN |
| Description: | mitogen-activated protein kinase 4 [Source:HGNC Symbol;Acc:6878] |
| Location: | chr18 q21.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S196 | TKWYRsPRLLL | Erk4(MAPK4 | RegPhos |
| S196 | TKWYRsPRLLL | Erk4 | RegPhos |
| S186 | HKGYLsEGLVT | HPRD; SysPTM | |
| S196 | TKWYRsPRLLL | MAPK4 | HPRD; phosphoELM |
| Dephosphorylation site |
| MK04_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000383234 | P246T | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000383234 | R272T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000383234 | D336N | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 |
| Differential expressed protein |
| MK04_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MK04_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK04_HUMAN | MK04_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| MK04_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0000165 | MAPK cascade | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004707 | MAP kinase activity | IEA | molecular_function |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0042803 | protein homodimerization activity | IEA | molecular_function |