| UniProt/SwissProt ID: | MEIS2_HUMAN |
| Description: | Meis homeobox 2 [Source:HGNC Symbol;Acc:7001] |
| Location: | chr15 q14 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S110 | DGSSKsDHEEL | HPRD | |
| S185 | DGSSKsDHEEL | HPRD | |
| S198 | DGSSKsDHEEL | HPRD | |
| Dephosphorylation site |
| MEIS2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000326296 | F283S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000404185 | F283S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000391887 | F283S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000339549 | F270S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000372216 | F283S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000380745 | F195S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000341400 | F283S | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| MEIS2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MEIS2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MEIS2_HUMAN | DRD1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| MEIS2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0001654 | eye development | IEA | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | TAS | biological_process |
| GO:0008134 | transcription factor binding | ISS | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003712 | transcription cofactor activity | ISS | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045638 | negative regulation of myeloid cell differentiatio | ISS | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0003714 | transcription corepressor activity | TAS | molecular_function |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |