Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MEFV_HUMAN
Description:Mediterranean fever [Source:HGNC Symbol;Acc:6998]
Location:chr16 p13.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y741ARSHIyTFASCSPRYPhosphoSitePlus
S11SDHLLsTLEELPYRINPhosphoSitePlus
S6MAKTPsDHLLSPYRINPhosphoSitePlus
S273AANLDsATEPRPhosphoSitePlus
S242KMRPRsLEVTIPhosphoSitePlus
Y732GSISFyNVTARSPRYPhosphoSitePlus
S208LRRNAsSAGRLPhosphoSitePlus
T672LGACKtSISRKSPRYPhosphoSitePlus
S209RRNASsAGRLQPhosphoSitePlus
T12DHLLStLEELVPYRINPhosphoSitePlus
T267TLEEKtAANLDPhosphoSitePlus
S673GACKTsISRKGSPRYPhosphoSitePlus

Dephosphorylation site
MEFV_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000219596D505NCOSMICMelanoma21499247
ENSP00000219596H739PCOSMICOvarian Cancer21720365
ENSP00000219596E456KBIOMARTBreast Cancer21930507, 21930502
ENSP00000219596S312ICOSMICOvarian Cancer21720365
ENSP00000219596R348HCOSMICOvarian Cancer21720365
ENSP00000219596W525*COSMICSkin Cancer21984974
ENSP00000219596R204CCOSMICCentral Nervous System Neoplasms18772396
ENSP00000219596G660*COSMICLung Cancer
ENSP00000219596R537KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
MEFV_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MEFV_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TF65_HUMANMEFV_HUMANTF -> target geneTRANSFAC
CEBPB_HUMANMEFV_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MEFV_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0006954inflammatory responseIDAbiological_process
GO:2001056positive regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0032691negative regulation of interleukin-1 beta productiIMPbiological_process
GO:0003779actin bindingIDAmolecular_function
GO:0045087innate immune responseTASbiological_process
GO:0005874microtubuleIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0050728negative regulation of inflammatory responseIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005875microtubule associated complexIDAcellular_component
GO:0071641negative regulation of macrophage inflammatory proIMPbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0008270zinc ion bindingNASmolecular_function
GO:0032695negative regulation of interleukin-12 productionIMPbiological_process
GO:0005515protein bindingIEAmolecular_function


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23