Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MCP_HUMAN
Description:CD46 molecule, complement regulatory protein [Source:HGNC Symbol;Acc:6953]
Location:chr1 q32.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y384DGGAEyATYQTHPRD
Y378KKKGTyLTDETPhosphoSitePlus
Y369DGGAEyATYQTHPRD
Y387AEYATyQTKSTHPRD
T303SHSVStSSTTKPhosphoSitePlus
Y343AEYATyQTKSTHPRD
Y340DGGAEyATYQTHPRD
Y372AEYATyQTKSTHPRD
Y357AEYATyQTKSTHPRD
Y354DGGAEyATYQTHPRD
T320SGPRPtYKPPVPhosphoSitePlus
Y353VVPYRyLQRRKYES1HPRD
Y368VVPYRyLQRRKYES1HPRD
Y324VVPYRyLQRRKYES1HPRD
Y338VVPYRyLQRRKYES1HPRD

Dephosphorylation site
MCP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000350893I350VTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000346912Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000350893Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000356008Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000350893I350VCOSMICCentral Nervous System Neoplasms18772890
ENSP00000313875Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000314664A323VSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000350346Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000354358Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000314664A323VBIOMARTColorectal Cancer21930507, 21930502
ENSP00000350893C228YSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000356009Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000314664C228YSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000314664Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000350893E382KCOSMICLung Cancer20668451
ENSP00000418471Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000314664C228YBIOMARTColorectal Cancer21930507, 21930502
ENSP00000353342Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000413543Y117*BIOMARTBreast Cancer21930507, 21930502
ENSP00000356014Y54*BIOMARTBreast Cancer21930507, 21930502
ENSP00000350893C228YHPIColorectal Cancer16959974
ENSP00000350893A353VCOSMICIntestines Cancer16959974

Differential expressed protein
MCP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MCP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
YES_HUMANMCP_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05162Measles
hsa04610Complement and coagulation cascades

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006958complement activation, classical pathwayIEAbiological_process
GO:0001669acrosomal vesicleIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0009986cell surfaceIEAcellular_component
GO:0007338single fertilizationIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0004872receptor activityTASmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0002079inner acrosomal membraneIEAcellular_component
GO:0006508proteolysisIEAbiological_process
GO:0001848complement bindingIEAmolecular_function
GO:0045916negative regulation of complement activationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0030449regulation of complement activationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component


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