| UniProt/SwissProt ID: | MCP_HUMAN |
| Description: | CD46 molecule, complement regulatory protein [Source:HGNC Symbol;Acc:6953] |
| Location: | chr1 q32.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y384 | DGGAEyATYQT | HPRD | |
| Y378 | KKKGTyLTDET | PhosphoSitePlus | |
| Y369 | DGGAEyATYQT | HPRD | |
| Y387 | AEYATyQTKST | HPRD | |
| T303 | SHSVStSSTTK | PhosphoSitePlus | |
| Y343 | AEYATyQTKST | HPRD | |
| Y340 | DGGAEyATYQT | HPRD | |
| Y372 | AEYATyQTKST | HPRD | |
| Y357 | AEYATyQTKST | HPRD | |
| Y354 | DGGAEyATYQT | HPRD | |
| T320 | SGPRPtYKPPV | PhosphoSitePlus | |
| Y353 | VVPYRyLQRRK | YES1 | HPRD |
| Y368 | VVPYRyLQRRK | YES1 | HPRD |
| Y324 | VVPYRyLQRRK | YES1 | HPRD |
| Y338 | VVPYRyLQRRK | YES1 | HPRD |
| Dephosphorylation site |
| MCP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000350893 | I350V | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000346912 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350893 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356008 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350893 | I350V | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000313875 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314664 | A323V | Sjoblom2006 | Intestines Cancer | 16959974, 21930507, 21930502 | ENSP00000350346 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000354358 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314664 | A323V | BIOMART | Colorectal Cancer | 21930507, 21930502 | ENSP00000350893 | C228Y | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000356009 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314664 | C228Y | Sjoblom2006 | Intestines Cancer | 16959974, 21930507, 21930502 | ENSP00000314664 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350893 | E382K | COSMIC | Lung Cancer | 20668451 | ENSP00000418471 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000314664 | C228Y | BIOMART | Colorectal Cancer | 21930507, 21930502 | ENSP00000353342 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000413543 | Y117* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356014 | Y54* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000350893 | C228Y | HPI | Colorectal Cancer | 16959974 | ENSP00000350893 | A353V | COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| MCP_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MCP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| YES_HUMAN | MCP_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05162 | Measles |
| hsa04610 | Complement and coagulation cascades |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006958 | complement activation, classical pathway | IEA | biological_process |
| GO:0001669 | acrosomal vesicle | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0007338 | single fertilization | IEA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0016323 | basolateral plasma membrane | IEA | cellular_component |
| GO:0004872 | receptor activity | TAS | molecular_function |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0002079 | inner acrosomal membrane | IEA | cellular_component |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0001848 | complement binding | IEA | molecular_function |
| GO:0045916 | negative regulation of complement activation | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0030449 | regulation of complement activation | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |