| UniProt/SwissProt ID: | MC5R_HUMAN |
| Description: | melanocortin 5 receptor [Source:HGNC Symbol;Acc:6933] |
| Location: | chr18 p11.21 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T143 | VDRYVtIFYAL | 7tm_1 | PhosphoSitePlus |
| T155 | YHHIMtARRSG | 7tm_1 | PhosphoSitePlus |
| Y150 | FYALRyHHIMT | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| MC5R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000318077 | V126L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000318077 | T171M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318077 | F306I | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000318077 | K27N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318077 | T171M | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000318077 | I153T | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| MC5R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MC5R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| COLI_HUMAN | MC5R_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0042562 | hormone binding | IEA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0030819 | positive regulation of cAMP biosynthetic process | IDA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004977 | melanocortin receptor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |