Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MARK4_HUMAN
Description:MAP/microtubule affinity-regulating kinase 4 [Source:HGNC Symbol;Acc:13538]
Location:chr19 q13.32
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T214GSKLDtFCGSPMARK4HPRD
S438LHPKRsPTSTGPhosphoSitePlus
T393RAPSDtTNGTSPhosphoSitePlus
S567GSTIRsTFHGGPhosphoSitePlus
T214GSKLDtFCGSPphosphoELM; RegPhos
S218DTFCGsPPYAAHPRD; phosphoELM
S48RNSIAsCPEEQPhosphoSitePlus
T64YRLLRtIGKGNPkinase_CAMKPhosphoSitePlus
T507PPSMMtRRNTYHPRD
S545PPASPsSHSLAPhosphoSitePlus
S45ARCRNsIASCPPhosphoSitePlus
S496RKDSTsTPNNLPhosphoSitePlus; HPRD
S504NNLPPsMMTRRPhosphoSitePlus; HPRD
S15GNDRNsDTHGTPhosphoSitePlus
T214GSKLDtFCGSPLKB1phosphoELM
T511MTRRNtYVCTEPhosphoSitePlus
T214GSKLDtFCGSPLKB1(STK11RegPhos
T568STIRStFHGGQPhosphoSitePlus
S563RLARGsTIRSTPhosphoSitePlus
T564LARGStIRSTFPhosphoSitePlus
T394APSDTtNGTSSPhosphoSitePlus
S594NGPPAsPTLAHPhosphoSitePlus
S546PASPSsHSLAPPhosphoSitePlus
S218DTFCGsPPYAAPkinase_CAMKPhosphoSitePlus
T440PKRSPtSTGEAPhosphoSitePlus
T214GSKLDtFCGSPPkinase_CAMKPhosphoSitePlus
S26LGSGRsSDKGPMARK4HPRD
S441KRSPTsTGEAEPhosphoSitePlus
S423RQRRHsDFCGPPhosphoSitePlus
S26LGSGRsSDKGPPhosphoSitePlus; phosphoELM; RegPhos
S391RVRAPsDTTNGPhosphoSitePlus

Dephosphorylation site
MARK4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262891G234WBIOMARTBrain Cancer21930507, 21930502
ENSP00000300843R418CGreenman2007Intestines Cancer17344846, 18428421
ENSP00000262891R410QTCGAOvarian Cancer21720365, 18772890
ENSP00000262891R418CHPIColorectal Cancer17344846
ENSP00000262891G24DTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000262891E350DTCGAOvarian Cancer21720365, 18772890
ENSP00000262891R418CGreenman2007Intestines Cancer17344846, 18428421

Differential expressed protein
MARK4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MARK4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANMARK4_HUMANkinase -> substrateRegPhos
MARK4_HUMANMARK4_HUMANkinase -> substrateHPRD
STK11_HUMANMARK4_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
MARK4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0001578microtubule bundle formationIEPbiological_process
GO:0007399nervous system developmentIDAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0043015gamma-tubulin bindingIDAmolecular_function
GO:0043068positive regulation of programmed cell deathNASbiological_process
GO:0050321tau-protein kinase activityIDAmolecular_function
GO:0008017microtubule bindingIDAmolecular_function
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0000226microtubule cytoskeleton organizationIMPbiological_process
GO:0043130ubiquitin bindingNASmolecular_function
GO:0005815microtubule organizing centerIDAcellular_component
GO:0043005neuron projectionIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0005515protein bindingIPImolecular_function


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