Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MARCS_HUMAN
Description:myristoylated alanine-rich protein kinase C substrate [Source:HGNC Symbol;Acc:6759]
Location:chr6 q21
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S163FSFKKsFKLSGphosphoELM; SysPTM
S147ATPSPsNETPKHPRD; phosphoELM; RegPhos; SysPTM
T150SPSNEtPKKKKHPRD; phosphoELM; RegPhos; SysPTM
S134AASSTsSPKAEHPRD; SysPTM
S159KKKRFsFKKSFPKC_groupphosphoELM; RegPhos; SysPTM
S128EGEAAsAASSTMARCKSPhosphoSitePlus
S170KLSGFsFKKNKPKCbRegPhos; SysPTM
S46VNGDAsPAAAEphosphoELM; RegPhos; SysPTM
S145DGATPsPSNETMARCKSPhosphoSitePlus; SysPTM
S167KSFKLsGFSFKPKC_groupphosphoELM; RegPhos; SysPTM
S170KLSGFsFKKNKPRKCAHPRD; SysPTM
S170KLSGFsFKKNKPRKCBHPRD; SysPTM
T133SAASStSSPKAMARCKSPhosphoSitePlus
S167KSFKLsGFSFKPRKCAHPRD; SysPTM
S46VNGDAsPAAAEMARCKSPhosphoSitePlus; SysPTM
S159KKKRFsFKKSFPKN1HPRD; RegPhos; SysPTM
S134AASSTsSPKAEMARCKSPhosphoSitePlus; SysPTM
S128EGEAAsAASSTHPRD; phosphoELM; RegPhos
S101PEAGAsPVEKEPKCaRegPhos; SysPTM
S163FSFKKsFKLSGMARCKSPhosphoSitePlus; SysPTM
S77PAAAGsGAASPHPRD; phosphoELM; RegPhos
S145DGATPsPSNETHPRD; phosphoELM; RegPhos; SysPTM
S29VASSPsKANGQMARCKSPhosphoSitePlus; SysPTM
S118AAEPGsPTAAEPRKCAHPRD; SysPTM
S101PEAGAsPVEKEMARCKSPhosphoSitePlus; SysPTM
S159KKKRFsFKKSFPKC_alphaphosphoELM; SysPTM
S27AAVASsPSKANPKCaRegPhos; SysPTM
S163FSFKKsFKLSGPKCa(PKC alphaRegPhos; SysPTM
S118AAEPGsPTAAEPKCaRegPhos; SysPTM
S46VNGDAsPAAAEPRKCAHPRD; SysPTM
S81GSGAAsPSAAEPRKCAHPRD
S131AASAAsSTSSPMARCKSPhosphoSitePlus; SysPTM
S83GAASPsAAEKGHPRD
S170KLSGFsFKKNKPKC_groupphosphoELM; RegPhos; SysPTM
S118AAEPGsPTAAEMARCKSPhosphoSitePlus; SysPTM
T143AEDGAtPSPSNHPRD; phosphoELM; RegPhos
S101PEAGAsPVEKEHPRD; phosphoELM; RegPhos; SysPTM
S170KLSGFsFKKNKPKCaRegPhos; SysPTM
S27AAVASsPSKANHPRD; phosphoELM; RegPhos; SysPTM
T150SPSNEtPKKKKMARCKSPhosphoSitePlus; SysPTM
S159KKKRFsFKKSFPKCa(PKC alphaRegPhos; SysPTM
S81GSGAAsPSAAEMARCKSPhosphoSitePlus
S163FSFKKsFKLSGPKCbRegPhos; SysPTM
S63LQANGsAPAADHPRD
S147ATPSPsNETPKMARCKSPhosphoSitePlus; SysPTM
T120EPGSPtAAEGEMARCKSPhosphoSitePlus
S170KLSGFsFKKNKMARCKSPhosphoSitePlus; SysPTM
S26EAAVAsSPSKAMARCKSPhosphoSitePlus; SysPTM
S159KKKRFsFKKSFphosphoELM; SysPTM
S135ASSTSsPKAEDMARCKSPhosphoSitePlus
S170KLSGFsFKKNKHPRD; phosphoELM; SysPTM
S159KKKRFsFKKSFMARCKSPhosphoSitePlus; SysPTM
S159KKKRFsFKKSFPKCbRegPhos; SysPTM
S159KKKRFsFKKSFPKCaRegPhos; SysPTM
S46VNGDAsPAAAEPKCaRegPhos; SysPTM
S167KSFKLsGFSFKphosphoELM; SysPTM
S29VASSPsKANGQHPRD; phosphoELM; RegPhos; SysPTM
S132ASAASsTSSPKHPRD
S26EAAVAsSPSKAHPRD; phosphoELM; RegPhos; SysPTM
S118AAEPGsPTAAEMAPK_groupRegPhos; SysPTM
S77PAAAGsGAASPMARCKSPhosphoSitePlus
S163FSFKKsFKLSGPKN1HPRD; RegPhos; SysPTM
S163FSFKKsFKLSGPKC_groupphosphoELM; RegPhos; SysPTM
S163FSFKKsFKLSGPRKCAHPRD; SysPTM
S163FSFKKsFKLSGPRKCBHPRD; SysPTM
S159KKKRFsFKKSFPRKCBHPRD; SysPTM
S159KKKRFsFKKSFPRKCAHPRD; SysPTM
T143AEDGAtPSPSNMARCKSPhosphoSitePlus
S170KLSGFsFKKNKPKN1HPRD; RegPhos; SysPTM
T120EPGSPtAAEGEHPRD; phosphoELM
S101PEAGAsPVEKEPRKCAHPRD; SysPTM
S167KSFKLsGFSFKPKCaRegPhos; SysPTM
S63LQANGsAPAADMARCKSPhosphoSitePlus
S167KSFKLsGFSFKMARCKSPhosphoSitePlus; SysPTM
S27AAVASsPSKANPRKCAHPRD; SysPTM
S262AAEEPsKVEEKHPRD; RegPhos
S81GSGAAsPSAAEPKCaRegPhos
S135ASSTSsPKAEDHPRD; phosphoELM; RegPhos
S118AAEPGsPTAAEphosphoELM; SysPTM
S27AAVASsPSKANMARCKSPhosphoSitePlus; SysPTM
S131AASAAsSTSSPHPRD; SysPTM
S163FSFKKsFKLSGPKCaRegPhos; SysPTM
S163FSFKKsFKLSGPKC_alphaphosphoELM; SysPTM
S132ASAASsTSSPKMARCKSPhosphoSitePlus
S81GSGAAsPSAAEphosphoELM; RegPhos

Dephosphorylation site
MARCS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000357624S314LBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000357624Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.318646787
ENSP00000357624Oral Premalignant LesionsNormal vs. CancertissueDown0.6719072117
ENSP00000357624Oral Premalignant LesionsNormal vs. CancertissueDown0.519072117
ENSP00000357624Oral Premalignant LesionsNormal vs. CancertissueDown0.5719072117
ENSP00000357624Oral Premalignant LesionsNormal vs. CancertissueDown0.6119072117
ENSP00000357624Oral Premalignant LesionsNormal vs. CancertissueDown0.7219072117
ENSP00000357624Oral Premalignant LesionsNormal vs. CancertissueDown0.619072117
ENSP00000357624Hepatocellular CarcinomaMetastasiscell lineUp1.919016532

Hyperphosphorylation site
MARCS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCB_HUMANMARCS_HUMANkinase -> substrateHPRD
PKN1_HUMANMARCS_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMARCS_HUMANkinase -> substrateRegPhos
KPCA_HUMANMARCS_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005938cell cortexIEAcellular_component
GO:0015629actin cytoskeletonTAScellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0051015actin filament bindingTASmolecular_function
GO:0050796regulation of insulin secretionTASbiological_process
GO:0005813centrosomeIEAcellular_component
GO:0006112energy reserve metabolic processTASbiological_process
GO:0042585germinal vesicleIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0005080protein kinase C bindingIEAmolecular_function