Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M4K3_HUMAN
Description:mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:6865]
Location:chr2 p22.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y31TYGDVyKARNVPkinasePhosphoSitePlus
S329EEKTRsEITFGPhosphoSitePlus
Y366SSEEIyYTARSPhosphoSitePlus
Y735VPEQEyPLVCVCNHPhosphoSitePlus
Y367SEEIYyTARSNPhosphoSitePlus
Y387GHQGGyFLGANPhosphoSitePlus
S661LPRKFsVSAKIHPRD
Y379DLQLEyGQGHQPhosphoSitePlus
T539NGLPPtPKVHMPhosphoSitePlus
S616NNCLLsISGKACNHPhosphoSitePlus
S616NNCLLsISGKAphosphoELM
S618CLLSIsGKASQCNHPhosphoSitePlus
S743VCVGVsRGRDFCNHPhosphoSitePlus
S533VPKPIsNGLPPPhosphoSitePlus
S170IAKRKsFIGTPPkinasePhosphoSitePlus
S24IQRIGsGTYGDPkinasePhosphoSitePlus
S398KSLLKsVEEELPhosphoSitePlus
Y27IGSGTyGDVYKPkinasePhosphoSitePlus
T327VREEKtRSEITPhosphoSitePlus
T26RIGSGtYGDVYPkinasePhosphoSitePlus
S280QHLTRsLAIELPhosphoSitePlus

Dephosphorylation site
M4K3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263881V182FDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263881E209DDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000263881T669SGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000263881E351KBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000263881D54NBIOMARTBreast Cancer21930507, 21930502
ENSP00000345434D54NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
M4K3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M4K3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M4K3_HUMANM3K1_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0016301kinase activityIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0006950response to stressIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007254JNK cascadeTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005083small GTPase regulator activityIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function


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